Pediatric HCT in Florida (2014 -2016): A report from the FPBCC.
Pediatric HCT in Florida (2014 -2016): A report from the FPBCC.
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佛罗里达州儿科 HCT（2014 年 -2016 年）：来自 FPBCC 的报告。
DOI：
10.1111/petr.13931
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发表时间：
2021
影响因子：
1.3
通讯作者：
Cline,Je
中科院分区：
文献类型：
--
作者：
Chellapandian,Deepak;Sunkersett,Gauri;Oshrine,Benjamin;GalvezSilva,Jorge;Ziga,Edward;Alperstein,Warren;Joyce,Michael;Katzenstein,Howard;Godder,Kamar;Castillo,Paul;Barredo,Julio;Fort,John;Shaw,PeterH;Nieder,MichaelL;Cline,Je
FPBCC 于 2018 年由佛罗里达州的五个儿科移植项目组成。该联盟的主要目标之一是通过结合所有参与中心的 HCT 数据来提供结果分析，以确定需要改进的领域。在第一份 FPBCC 概况报告中，我们描述了 2014 年至 2016 年在佛罗里达州接受首次同种异体和自体 HCT 的儿科患者的患者和移植特征。数据来源为CIBMTR的eDBtC。 3 年时间里，参与中心共有 230 名儿童患者接受了异体 HCT，104 名儿童患者接受了自体 HCT。患有恶性疾病的异基因 HCT 受者中最重要的生存预测因素是 HLA 匹配程度，而患有非恶性疾病的异基因 HCT 受者中，生存预测因素包括年龄、供者关系和 HLA 匹配程度。我们的分析表明，鉴于 HLA 匹配程度仍然是最重要的生存预测因素，因此需要改进主要死因的报告并改进捐赠者选择流程。第一次 FPBCC 全范围审查描述了佛罗里达州参与中心 2014 年至 2016 年间儿科 HCT 活动的趋势，并确认了使用 eDBtC 数据平台和协作方法以确定结果需要改进的领域的可行性。
FPBCC was formed in 2018 by five pediatric transplant programs in Florida. One of the key objectives of the consortium is to provide outcome analyses by combining HCT data from all the participating centers in order to identify areas for improvement. In this first FPBCC landscape report we describe the patient and transplant characteristics of pediatric patients undergoing first allo and auto HCT between 2014 and 2016 in Florida. The source of data was eDBtC of the CIBMTR. Over the span of 3 years, a total of 230 pediatric patients underwent allo‐HCT and 104 underwent auto‐HCT at the participating centers. The most significant predictor of survival in allo‐HCT recipients with malignant disorders was the degree of HLA‐ match, while in the recipients of allo‐HCT with non‐malignant disorders the predictors of survival included age, donor relationship and degree of HLA match. Our analyses identified the need to improve reporting of primary cause of death and improve on donor selection process given that the degree of HLA match remains the most important predictor of survival. This first FPBCC‐wide review describes the trends in pediatric HCT activity between 2014 and 2016 among the participating centers in Florida and confirms feasibility of using eDBtC data platform and collaborative approach in order to identify areas for improvement in outcomes.