THE EFFECT OF GLUCOSE LOADS ON RENAL URIC ACID EXCRETION IN DIABETIC PATIENTS.
THE EFFECT OF GLUCOSE LOADS ON RENAL URIC ACID EXCRETION IN DIABETIC PATIENTS.
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DOI：
10.1016/0026-0495(64)90137-4
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发表时间：
1964-06
期刊：
影响因子：
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通讯作者：
J. Padova;A. Patchefsky;G. Onesti;G. Faludi;G. Bendersky
中科院分区：
文献类型：
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作者：
J. Padova;A. Patchefsky;G. Onesti;G. Faludi;G. Bendersky
尽管糖尿病患者出现高尿酸血症，并且对碳水化合物与尿酸代谢进行了各种观察，15但利用葡萄糖负荷的尿酸排泄活性技术，尿酸清除率研究未能发现轻度糖尿病患者尿酸清除率的缺陷。发现 5 名糖尿病受试者在服用口服葡萄糖负荷后，尿酸清除率和尿酸清除率/肌酐清除率比值有所增加。 5 名受试者中有 4 名的血清尿酸水平也略有下降。研究的糖尿病患者表现出的葡萄糖排尿酸活性在质量上与非糖尿病患者相当。葡萄糖的这种影响可以解释临床观察到的痛风随糖尿病发作而改善的情况，但不足以防止高尿酸血症与高血糖的偶尔共存。
Despite the occurrence of hyperuricemia in diabetic patients and the various observations relating carbohydrate with uric acid metabolism,15uric acid clearance studies failed to uncover a defect of uric acid clearance in mild diabetics, utilizing a technic of uricosuric activity of glucose loads. Uric acid clearances and uric acid clearance/creatinine clearance ratios were found to increase in 5 diabetic subjects following administration of oral glucose loads. In 4 of the 5 subjects there was also a slight decrease in the serum uric acid levels. The diabetics studied exhibited a uricosuric acition of glucose comparable qualitatively to nondiabetics. This influence of glucose may explain the clinically observed improvement of gout with the onset of diabetes, but is not adequate to prevent the occasional coexistence of hyperuricemia with hyperglycemia.