PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus
PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus
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PPARG 多态性与 2 型糖尿病患者不明原因的轻度视力丧失相关
DOI：
10.1155/2019/5284867
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发表时间：
2019-12-12
影响因子：
1.9
通讯作者：
Zou, Haidong
中科院分区：
文献类型：
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作者：
Li, Tao;Xu, Xian;Zou, Haidong
目的探讨过氧化物酶体增殖物激活受体γ (PPARG)基因多态性是否与2型糖尿病（T2DM）患者不明原因轻度视力障碍（UMVI）相关。方法纳入135例伴有UMVI的T2DM患者和133例视力正常（双眼最佳矫正视力≥20/25）的患者。UMVI定义为双眼最佳矫正视力(BCVA) < 20/25和≥20/63，未发现视力损害引起的疾病。采用HAPLOVIEW 4.0软件对4个PPARG基因单核苷酸多态性（rs3856806、rs1801282、rs709158和rs10865710）进行评估，检验PPARG多态性与T2DM患者UMVI的统计学相关性。结果4个snp符合Hardy-Weinberg平衡（p < 0.05）。SNP rs10865710基因型GC的频率在UMVI组显著高于NV组（p < 0.001; GG + GC vs . CC） （OR = 8.94, 95% CI: 4.90-16.31），而基因型CC降低了风险（OR = 0.07, 95% CI: 0.03-0.14）。SNP rs3856806基因型TT与UMVI密切相关（p < 0.0001, TT + TC vs . CC） （OR = 4.74, 95% CI: 2.68-8.54），而基因型CC似乎对UMVI具有保护作用（OR = 0.55, 95% CI: 0.37-0.82）。结论PPARG变异的易感性可能导致PPARG转录差异，导致视网膜感光细胞早期功能丧失，最终导致UMVI。
Objectives To investigate whether the presence of peroxisome proliferator-activated receptor gamma (PPARG) gene polymorphisms is associated with unexplained mild visual impairment (UMVI) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 135 T2DM residents with UMVI and 133 with normal vision (NV; best-corrected visual acuity ≥ 20/25 in both eyes) were enrolled. UMVI was defined as best-corrected visual acuity (BCVA) < 20/25 and ≥ 20/63 in both eyes, with no visual impairment-causing diseases found. Four PPARG gene single-nucleotide polymorphisms (SNPs) (rs3856806, rs1801282, rs709158, and rs10865710) were assessed with the HAPLOVIEW 4.0 software to examine the statistical association of PPARG polymorphisms and UMVI in patients with T2DM. Results Four SNPs qualified the Hardy–Weinberg equilibrium (p > 0.05). The frequency of genotype GC at SNP rs10865710 was significantly higher in the UMVI group than in the NV group (p < 0.001; GG + GC versus CC) (OR = 8.94, 95% CI: 4.90–16.31), whereas genotype CC decreased the risk (OR = 0.07, 95% CI: 0.03–0.14). Genotype TT at SNP rs3856806 was strongly associated with UMVI (p < 0.0001, TT + TC versus CC) (OR = 4.74, 95% CI: 2.68–8.54), whereas genotype CC appeared to be protective for UMVI (OR = 0.55, 95% CI: 0.37–0.82). Conclusions Susceptibilities of PPARG variants may lead to differences in PPARG transcription, result in early function loss of retinal photoreceptor cells, and eventually cause UMVI.