A human memory circuit derived from brain lesions causing amnesia
A human memory circuit derived from brain lesions causing amnesia
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DOI：
10.1038/s41467-019-11353-z
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发表时间：
2019-08-02
影响因子：
16.6
通讯作者：
Fox, Michael D.
中科院分区：
文献类型：
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作者：
Ferguson, Michael A.;Lim, Chun;Fox, Michael D.
人类的记忆被认为依赖于连接的大脑区域的回路，但这一假设尚未得到直接验证。我们利用53例中风导致健忘症的病例报告和人类连接体图（n = 1000）得出了人类记忆回路。该回路在发现组（n = 27）和复制组（n = 26）中是可重复的，并且对引起健忘症的病变具有特异性。它的中枢位于枕前和脾后皮层的交界处。与这一单一位置的连接定义了人类大脑回路，其中包含了95%的导致健忘症的病变。在两个独立的数据集（N1 = 97, N2 = 176）中，与该回路相交的病变可以预测记忆分数。该网络与情景记忆、阿尔茨海默病异常以及据报道可增强人类记忆的脑刺激部位的神经影像学相关一致。
Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer's disease, and brain stimulation sites reported to enhance memory in humans.