Effects of Diet, Aerobic Exercise, or Both on Non-HDL-C in Adults: A Meta-Analysis of Randomized Controlled Trials.
Effects of Diet, Aerobic Exercise, or Both on Non-HDL-C in Adults: A Meta-Analysis of Randomized Controlled Trials.
复制标题
DOI：
10.1155/2012/840935
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kelley KS
中科院分区：
文献类型：
--
作者：
Kelley GA;Kelley KS
目的.采用荟萃分析方法研究饮食（D）、有氧运动（E）或两者（DE）对成人非高密度脂蛋白胆固醇（non-HDL-C）的影响。方法.纳入了在≥18岁成人中进行的随机对照试验。使用混合效应模型合并每个亚组内的联合收割机效应量（ES）结果，并比较亚组（Q B）。使用Q和I2统计量检查异质性，并计算95%置信区间（CI）。统计学显著性设定为P ≤ 0.05，而统计学显著性趋势设定为P > 0.05且≤0.10。结果运动组与对照组相比，DE组的非HDL-C降低具有统计学意义，（7个ES，389名受试者，mg/dL，95% CI = −21.7至−0.6，P = 0.04，Q = 2.4，P = 0.88，I 2 = 0%），D组的趋势（7个ES，402名参与者，mg/dL，95% CI = −18.6至1.6，P = 0.10，Q = 0.76，P = 0.99，I 2 = 0%），E组无变化（7个ES，387名受试者，mg/dL，95% CI = −7.1至13.1，P = 0.56，Q = 0.78，P = 0.99，I 2 = 0%）。总体而言，未发现具有统计学意义的组间差异（Q B = 4.1，P = 0.12）。结论.在某些情况下，饮食结合有氧运动可能会降低成年人的非HDL-C。
Purpose. To use the meta-analytic approach to examine the effects of diet (D), aerobic exercise (E), or both (DE) on non-high-density lipoprotein cholesterol (non-HDL-C) in adults. Methods. Randomized controlled trials in adults ≥18 years of age were included. A mixed-effect model was used to combine effect size (ES) results within each subgroup and to compare subgroups (Q b). Heterogeneity was examined using the Q and I 2 statistics, and 95% confidence intervals (CI) were also calculated. Statistical significance was set at P ≤ 0.05, while a trend for statistical significance was set between P > 0.05, and ≤0.10. Results. A statistically significant exercise minus control group decrease in non-HDL-C was found for DE (7 ESs, 389 participants, mg/dL, 95% CI = −21.7 to −0.6, P = 0.04, Q = 2.4, P = 0.88, I 2 = 0%), a trend for the D group (7 ESs, 402 participants, mg/dL, 95% CI = −18.6 to 1.6, P = 0.10, Q = 0.76, P = 0.99, I 2 = 0%), and no change for the E group (7 ESs, 387 participants, mg/dL, 95% CI = −7.1 to 13.1, P = 0.56, Q = 0.78, P = 0.99, I 2 = 0%). Overall, no statistically significant between-group differences were found (Q b = 4.1, P = 0.12). Conclusions. Diet combined with aerobic exercise may reduce non-HDL-C among adults in some settings.