DOPAMINE D2 RECEPTORS IN NORMAL HUMAN BRAIN - EFFECT OF AGE MEASURED BY POSITRON EMISSION TOMOGRAPHY (PET) AND [C-11] RACLOPRIDE
DOPAMINE D2 RECEPTORS IN NORMAL HUMAN BRAIN - EFFECT OF AGE MEASURED BY POSITRON EMISSION TOMOGRAPHY (PET) AND [C-11] RACLOPRIDE
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DOI：
10.1111/j.1749-6632.1993.tb23033.x
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发表时间：
1993-01-01
期刊：
影响因子：
--
通讯作者：
LEENDERS, KL
中科院分区：
文献类型：
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作者：
ANTONINI, A;LEENDERS, KL
人类尸检和动物实验结果表明，随着年龄的增长，大脑多巴胺能神经元系统的下降。在这项研究中，放射性示踪剂[C-11]雷氯必利（多巴胺D2拮抗剂）和正电子发射断层扫描，以确定年龄对纹状体多巴胺D2受体在32名健康志愿者（年龄范围21-68岁）的影响。受试者根据中位年龄（31岁）分为两个年龄组。计算尾状核和壳核的特异性示踪剂摄取指数。老年组受试者的摄取指数平均降低26%，在壳核和20%，在尾状核。直到30年前，下降幅度似乎很大，但之后有所减缓。30岁后，发现特异性雷氯必利结合率每年下降0.6%。这些结果表明，多巴胺D2受体结合位点（主要位于突触后）减少作为正常老化的结果与突触前黑质纹状体多巴胺能系统的下降平行。
Human post-mortem and animal experimental results suggest a decline of the cerebral dopaminergic neuronal system with age. In this study, the radiotracer [C-11]raclopride (dopamine D2 antagonist) and positron emission tomography were applied to determine the effect of age on striatal dopamine D2 receptors in 32 healthy volunteer subjects (age range 21-68 years). Subjects were divided in two age groups on the basis of median age (31 years). An index for specific tracer uptake was calculated for caudate nucleus and putamen. Uptake indices in the older group of subjects were reduced on average 26% in putamen and 20% in caudate nucleus. The decline appeared to be steep until 30 years, but slower afterwards. After 30 years of age the decline of specific raclopride binding was found to be 0.6% per year. These results suggest that dopamine D2 receptor binding sites (mainly post-synaptically located) decrease as a consequence of normal aging in parallel with the decline of the pre-synaptic nigrostriatal dopa-minergic system.