Increased Glutamate/Glutamine Compounds in the Brains of Patients With Fibromyalgia A Magnetic Resonance Spectroscopy Study
Increased Glutamate/Glutamine Compounds in the Brains of Patients With Fibromyalgia A Magnetic Resonance Spectroscopy Study
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DOI：
10.1002/art.27430
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发表时间：
2010-06-01
影响因子：
--
通讯作者：
Salamero, Manel
中科院分区：
文献类型：
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作者：
Valdes, Manuel;Collado, Antonio;Salamero, Manel
客观的。纤维肌痛（FM）被定义为一种全身性疾病，其临床特征为疼痛、认知缺陷和相关精神病理学的存在，所有这些都提示原发性脑功能障碍。本研究旨在通过磁共振波谱 (MRS) 技术评估 FM 患者的大脑代谢模式，以确定这种脑功能障碍的性质。方法。研究人员对 28 名 FM 女性患者和 24 名同龄健康女性的对照组进行了研究。 MRS 技术被用来研究这些女性杏仁核、丘脑和前额皮质的大脑代谢物。结果。与健康对照相比，FM 患者的谷氨酸/谷氨酰胺 (Glx) 化合物水平较高（平均值 +/- SD 11.9 +/- 1.6 任意单位 [AU]，对照和患者分别为 13.4 +/- 1.7 AU；t = 2.517, 35 df，校正 P = 0.03）和较高的 Glx：肌酸比率（平均值 +/- SD 2.1）右侧杏仁核分别为 +/- 0.4 与 2.4 +/- 1.4；t = 2.373, 35 df，校正后的 P = 0.04)。在疼痛强度增加、疲劳程度增加和抑郁症状更多的 FM 患者中，右侧杏仁核和右侧丘脑的肌醇水平显着升高。结论。 FM 患者右侧杏仁核中发现的独特代谢特征表明情绪处理中可能存在神经功能障碍。该结果似乎扩展了之前关于 FM 患者疼痛处理功能障碍的发现。
Objective. Fibromyalgia (FM) has been defined as a systemic disorder that is clinically characterized by pain, cognitive deficit, and the presence of associated psychopathology, all of which are suggestive of a primary brain dysfunction. This study was undertaken to identify the nature of this cerebral dysfunction by assessing the brain metabolite patterns in patients with FM through magnetic resonance spectroscopy (MRS) techniques.Methods. A cohort of 28 female patients with FM and a control group of 24 healthy women of the same age were studied. MRS techniques were used to study brain metabolites in the amygdala, thalami, and prefrontal cortex of these women.Results. In comparison with healthy controls, patients with FM showed higher levels of glutamate/glutamine (Glx) compounds (mean +/- SD 11.9 +/- 1.6 arbitrary units [AU] versus 13.4 +/- 1.7 AU in controls and patients, respectively; t = 2.517, 35 df, corrected P = 0.03) and a higher Glx: creatine ratio (mean +/- SD 2.1 +/- 0.4 versus 2.4 +/- 1.4, respectively; t = 2.373, 35 df, corrected P = 0.04) in the right amygdala. In FM patients with increased levels of pain intensity, greater fatigue, and more symptoms of depression, inositol levels in the right amygdala and right thalamus were significantly higher.Conclusion. The distinctive metabolic features found in the right amygdala of patients with FM suggest the possible existence of a neural dysfunction in emotional processing. The results appear to extend previous findings regarding the dysfunction in pain processing observed in patients with FM.