Achromobacter xylosoxidans bacteremia:: A 10-year analysis of 54 cases
Achromobacter xylosoxidans bacteremia:: A 10-year analysis of 54 cases
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DOI：
10.1007/s10096-003-0925-3
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发表时间：
2003-06-01
影响因子：
4.5
通讯作者：
Vázquez, JJ
中科院分区：
文献类型：
--
作者：
Gómez-Cerezo, J;Suárez, I;Vázquez, JJ
研究人员回顾了 10 年间诊断出的 54 例木糖氧化无色杆菌菌血症患者，患者年龄从 2 个月到 87 岁。 52 起事件是院内事件。最常见的潜在病症是肿瘤（实体或血液肿瘤）。 35 名患者（60%）的感染源是受污染的静脉导管，6 名患者是肺炎。八名（15%）患者死亡。与死亡率显着相关的唯一危险因素是年龄超过 65 岁和中性粒细胞减少症。分离株的体外药敏研究结果表明，抗假单胞菌青霉素或碳青霉烯类抗生素治疗是合理的选择。在血液透析室进行的一项流行病学研究显示，自来水和两名医护人员的手上存在木糖氧化无色杆菌，但血液透析系统中却没有。当医护人员在不戴手套的情况下操作静脉导管时，患者可能受到污染。
Fifty-four cases of Achromobacter xylosoxidans bacteremia diagnosed over a 10-year period in patients from 2 months to 87 years of age were reviewed. Fifty-two episodes were nosocomial. The most frequent underlying condition was neoplasm (solid or hematological). The source of infection was a contaminated intravenous catheter in 35 patients (60%) and pneumonia in 6 patients. Eight (15%) patients died. The only risk factors significantly associated with mortality were age over 65 years and neutropenia. The results of in vitro susceptibility studies of the isolates showed that antibiotic therapy with antipseudomonal penicillins or carbapenems would be a reasonable choice. An epidemiological study conducted in the hemodialysis unit showed Achromobacter xylosoxidans in tap water and on the hands of two healthcare workers but not in the hemodialysis systems. Patients were probably contaminated when healthcare workers manipulated the intravenous catheters without wearing gloves.