Closing the structure-to-function gap for LRRK2.
Closing the structure-to-function gap for LRRK2.
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DOI：
10.1016/j.tibs.2021.10.003
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发表时间：
2021-10
影响因子：
13.8
通讯作者：
V. Tokars;Chuyu Chen;L. Parisiadou
中科院分区：
文献类型：
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作者：
V. Tokars;Chuyu Chen;L. Parisiadou
rrk2基因的变异是帕金森病（PD）最重要的遗传因素之一。很明显，对编码的大型多结构域LRRK2蛋白的结构知识将有助于阐明其生物学功能。Myasnikov， Zhu等人的新研究提供了全长LRRK2的高分辨率结构。
Variations in theLRRK2gene represent one of the strongest genetic factors for Parkinson's disease (PD). It has become clear that structural knowledge of the encoded large multidomain LRRK2 protein will cast light on its biological function. The new study from Myasnikov, Zhu, et al. provides a high-resolution structure of the full-length LRRK2.