Cracking the Cell Death Code.
Cracking the Cell Death Code.
复制标题
破解细胞死亡密码。
DOI：
10.1101/cshperspect.a036343
复制
发表时间：
2020
影响因子：
7.2
通讯作者：
Ghosh,Sourav
中科院分区：
文献类型：
--
作者：
Rothlin,CarlaV;Ghosh,Sourav
细胞死亡是我们整个生命周期中不变的特征，从形态发生期间广泛的计划性细胞死亡开始，并在成体组织中的稳态下继续死亡。此外，细胞在受伤和感染后会成为意外的、计划外的死亡的受害者。在每一种情况下，细胞死亡都会触发它们周围的活细胞或被垂死/死亡细胞吸引的活细胞中的特定和专门的反应。这些反应在形态发生期间塑造组织，在稳态中补充丢失的细胞以维持组织/系统功能，并在损伤后修复受损组织。其中的信息，设置在运动级联效应反应最终在重塑，更新，或修复？在这里，我们试图提供一个框架来思考细胞死亡的特定效应反应，伴随着各种形式的细胞死亡。我们还提出了一个集成的三重“细胞死亡代码”，包括内在的死亡/死亡细胞的信息，死亡细胞的周围环境，和响应者的身份。
Cell death is an invariant feature throughout our life span, starting with extensive scheduled cell death during morphogenesis and continuing with death under homeostasis in adult tissues. Additionally, cells become victims of accidental, unscheduled death following injury and infection. Cell death in each of these occasions triggers specific and specialized responses in the living cells that surround them or are attracted to the dying/dead cells. These responses sculpt tissues during morphogenesis, replenish lost cells in homeostasis to maintain tissue/system function, and repair damaged tissues after injury. Wherein lies the information that sets in motion the cascade of effector responses culminating in remodeling, renewal, or repair? Here, we attempt to provide a framework for thinking about cell death in terms of the specific effector responses that accompanies various modalities of cell death. We also propose an integrated threefold “cell death code” consisting of information intrinsic to the dying/dead cell, the surroundings of the dying cell, and the identity of the responder.