The stress activated protein kinase pathway.
The stress activated protein kinase pathway.
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应激激活蛋白激酶途径。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
J. Kyriakis
中科院分区：
文献类型：
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作者：
J. Woodgett;J. Avruch;J. Kyriakis
SAPKs代表了细胞损伤或损伤的作用传递到细胞核以影响基因表达的新管道。SAPK途径由至少四种水平的蛋白激酶组成，这些蛋白激酶被广泛的对细胞生长产生不利影响的试剂激活。与结构相关的MAPK途径不同，应激诱导的激酶不是有丝分裂所需的，而是诱导生长停滞。鉴于炎症细胞因子、再灌注损伤和化疗对该通路的调节，确定该通路的生理功能可能会发现诊断和治疗干预的新可能性。
The SAPKs represent novel conduits through which the effects of cellular insults or injury are transmitted to the nucleus to influence gene expression. The SAPK pathway consists of at least four levels of protein kinases that are activated by a wide range of agents that adversely affect cell growth. Unlike the structurally related MAPK pathway, the stress induced kinases are not required for mitogenesis and instead induce growth arrest. Given the modulation of the pathway by inflammatory cytokines, reperfusion injury and chemotherapeutics, determination of the physiological functions of the pathway may uncover new possibilities for diagnosis and therapeutic intervention.