The CYPP450 arachidonic acid monooxygenases: From cell signaling to blood pressure regulation
The CYPP450 arachidonic acid monooxygenases: From cell signaling to blood pressure regulation
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DOI：
10.1006/bbrc.2001.5167
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发表时间：
2001-07-20
影响因子：
3.1
通讯作者：
Falck, JR
中科院分区：
文献类型：
--
作者：
Capdevila, JH;Falck, JR
细胞色素P450（P450）花生四烯酸（AA）单加氧酶是AA生物活化的主要途径，近年来的研究发现，该酶系统在细胞和器官生理学以及内源性底物代谢中具有新的重要功能。P450生物化学和分子生物学的过去和现在的进展开始提供AA生物活化的P450亚型特异性的描述，以及P450代谢物的作用机制和生理相关性。P450功能、表达或调节的遗传控制改变与功能上有意义的表型之间的关联表明AA单加氧酶在控制全身血压和高血压的病理生理学中起着关键作用。(C)北京：科学出版社.
The studies of the cytochrome P450 (P450) arachidonic acid (AA) monooxygenase, now established as a major pathway for the bioactivation of AA, have uncovered new and important functional roles for this enzyme system in cell and organ physiology, and in the metabolism of endogenous substrate. Past and present advances in P450 biochemistry and molecular biology are beginning to provide a description of the P450 isoform specificity of AA bioactivation, and the mechanisms of action and physiological relevance of the P450 metabolites. Associations between genetically controlled alterations in P450 function, expression, or regulation and functionally meaningful phenotypes point to the critical roles played by the AA monooxygenase in the control of systemic blood pressure and the pathophysiology of hypertension. (C) 2001 Academic Press.