Very high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK Biobank Cohort.
Very high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK Biobank Cohort.
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DOI：
10.1017/s0007114520002779
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发表时间：
2021-02-28
期刊：
影响因子：
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通讯作者：
Lanham-New SA
中科院分区：
文献类型：
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作者：
Darling AL;Blackbourn DJ;Ahmadi KR;Lanham-New SA
在相对较大的样本量中，很少有研究评估居住在西方的南亚人的血清25-羟基维生素D （25(OH)D）浓度及其预测因子。这项观察性横断面分析评估了居住在英国的南亚人（40-69岁，2006-2010）25(OH)D缺乏症的基线患病率。血清25(OH)D测定采用DiaSorin Liaison XL法。在6433名25(OH)D检测的南亚人中，使用常用的截止阈值，55% （n 3538）的25(OH)D < 25 nmol/l（严重缺乏），92% （n 5918）的25(OH)D < 50 nmol/l（不足）。在接受测量的参与者中，20% （n 1287）的25(OH)D浓度<15 nmol/l（非常严重的缺乏）。当824名25(OH)D测量值无法检测（<10 nmol/l）的参与者（总n 7257）， 29% （n 2105）的25(OH)D < 15 nmol/l, 60% （n 4354）的25(OH)D < 25 nmol/l, 93% （n 6749）的25(OH)D < 50 nmol/l。25(OH)D < 25 nmol/l的Logistic回归预测因子包括：男性；巴基斯坦;高体重指数;40-59岁；不要食用油性鱼类；夏季日晒<5小时/天，未使用含维生素d的补充剂，在冬季或春季测量并素食。从地区来看，苏格兰、英格兰北部、中部和威尔士的25(OH)D浓度中位数为19-20 nmol/l。在整个英格兰南部和伦敦，它略高，为24-25 nmol/l。我们的分析表明，需要提高对南亚人维生素D缺乏症的认识，以及紧急的公共卫生干预措施，以预防和治疗这一群体的维生素D缺乏症。
Little research has assessed serum 25-hydroxyvitamin D (25(OH)D) concentration and its predictors in Western-dwelling South Asians in a relatively large sample size. This observational, cross-sectional analysis assessed baseline prevalence of 25(OH)D deficiency in UK-dwelling South Asians (aged 40–69 years, 2006–2010) from the UK Biobank Cohort. Serum 25(OH)D measurements were undertaken using the DiaSorin Liaison XL assay. Of 6433 South Asians with a 25(OH)D measurement, using commonly used cut-off thresholds, 55 % (n 3538) had 25(OH)D < 25 nmol/l (severe deficiency) and 92 % (n 5918) had 25(OH)D < 50 nmol/l (insufficiency). Of the participants with a measurement, 20 % (n 1287) had 25(OH)D concentration <15 nmol/l (very severe deficiency). When 824 participants with undetectable (<10 nmol/l) 25(OH)D measurements were included (total n 7257), 29 % (n 2105) had 25(OH)D < 15 nmol/l, 60 % (n 4354) had 25(OH)D < 25 nmol/l and 93 % (n 6749) had 25(OH)D < 50 nmol/l. Logistic regression predictors of 25(OH)D < 25 nmol/l included the following characteristics: being male; Pakistani; higher BMI; 40–59 years old; never consuming oily fish; summer sun exposure <5 h/d, not using a vitamin D-containing supplement, measurement in winter or spring and vegetarianism. In terms of region, median 25(OH)D concentration was 19–20 nmol/l in Scotland, Northern England, the Midlands and Wales. Across Southern England and London, it was slightly higher at 24–25 nmol/l. Our analyses suggest the need for increased awareness of vitamin D deficiency in South Asians as well as urgent public health interventions to prevent and treat vitamin D deficiency in this group.