Emerging strategies to effectively target autophagy in cancer.
Emerging strategies to effectively target autophagy in cancer.
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DOI：
10.1038/onc.2015.99
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发表时间：
2016-01-07
期刊：
影响因子：
8
通讯作者：
Amaravadi RK
中科院分区：
文献类型：
--
作者：
Rebecca VW;Amaravadi RK
自噬在癌症中发挥着双重作用，最近的进展有助于确定抑制或促进自噬可能为患者带来治疗效果的适当环境。我们对负责严格控制这种稳态机制的分子机制的不断发展的理解已经开始在以自噬为导向的临床试验中取得成果，并有希望通过先导化合物来调节自噬以获得治疗效果。在这篇手稿中，我们回顾了最近涉及癌症自噬调节的临床前和临床治疗策略。
Autophagy serves a dichotomous role in cancer and recent advances have helped delineate the appropriate settings where inhibiting or promoting autophagy may confer therapeutic efficacy in patients. Our evolving understanding of the molecular machinery responsible for the tightly controlled regulation of this homeostatic mechanism has begun to bear fruit in the way of autophagy-oriented clinical trials and promising lead compounds to modulate autophagy for therapeutic benefit. In this manuscript we review the recent preclinical and clinical therapeutic strategies that involve autophagy modulation in cancer.