Negative Affect Heightens Opiate Withdrawal-Induced Hyperalgesia in Heroin Dependent Individuals
Negative Affect Heightens Opiate Withdrawal-Induced Hyperalgesia in Heroin Dependent Individuals
复制标题
DOI：
10.1080/10550887.2011.581985
复制
发表时间：
2011-01-01
影响因子：
2.3
通讯作者：
Meagher, Mary W.
中科院分区：
文献类型：
--
作者：
Carcoba, Luis M.;Contreras, Arturo E.;Meagher, Mary W.
本研究探讨情绪对阿片类戒断引起的痛觉过敏的影响，以确定情绪状态是否调节痛觉过敏的程度。100名西班牙裔男子被招募到三组之一：海洛因戒断，长期海洛因戒断，和控制。研究人员向参与者展示图片，以诱导中性，积极和消极的情绪状态。测量情感效价、唤醒、痛阈和对缺血性疼痛的耐受性。当比较疼痛阈值和耐受性时，戒断组在诱发负性情绪时表现出显著的疼痛敏感性增加。作者还发现，前海洛因成瘾者在禁欲数月后表现出更高的疼痛敏感性。
This study examined the effect of emotion on opiate withdrawal induced hyperalgesia to determine whether emotional states modulate the magnitude of hyperalgesia. One hundred Hispanic men were recruited into one of three groups: heroin withdrawal, long-term heroin abstinence, and control. Participants were presented with pictures to induce neutral, positive, and negative emotional states. Affective valence, arousal, pain threshold, and tolerance to ischemic pain were measured. When pain threshold and tolerance were compared, the withdrawal group displayed significant heightened pain sensitivity when negative affect was induced. The authors also found that former heroin addicts showed heightened pain sensitivity following months of abstinence.