Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003-2006.
Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003-2006.
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DOI：
10.2337/dc09-0924
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发表时间：
2010-02
期刊：
影响因子：
16.2
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zhao G;Ford ES;Li C
研究美国无糖尿病成人血清25-羟基维生素D （25[OH]D）和甲状旁腺激素（PTH）浓度是否与胰岛素抵抗（IR）的替代标志物相关。对2003-2006年全国健康与营养检查调查（NHANES）的横断面数据（n = 3,206）进行分析。高胰岛素血症、高稳态模型评估- ir、高GHb、空腹和2小时高血糖的年龄调整患病率在25(OH)D的五分位数中呈线性下降，但在PTH的五分位数中呈线性上升（除了空腹高血糖呈二次型趋势）。在对潜在混杂因素进行广泛调整后，25(OH)D与IR和2小时高血糖标志物之间的关系仍然存在。只有高胰岛素血症与PTH呈正相关（P < 0.05）。在没有医生诊断为糖尿病的美国成年人中，低浓度的血清25(OH)D与IR标志物相关。甲状旁腺激素在IR中的作用值得进一步研究。
To examine whether concentrations of serum 25-hydroxyvitamin D (25[OH]D) and parathyroid hormone (PTH) are associated with surrogate markers of insulin resistance (IR) in U.S. adults without physician-diagnosed diabetes. Cross-sectional data (n = 3,206) from the National Health and Nutrition Examination Survey (NHANES) 2003–2006 were analyzed. The age-adjusted prevalence of hyperinsulinemia, high homeostasis model assessment-IR, high GHb, and fasting and 2-h hyperglycemia decreased linearly across quintiles of 25(OH)D but increased linearly across quintiles of PTH (except for a quadratic trend for fasting hyperglycemia). After extensive adjustment for potential confounders, the relationships between 25(OH)D and the markers of IR and 2-h hyperglycemia persisted. Only hyperinsulinemia was positively associated with PTH (P < 0.05). Among U.S. adults without physician-diagnosed diabetes, low concentrations of serum 25(OH)D were associated with markers of IR. The role of PTH in IR deserves further investigation.