Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study.
Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study.
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DOI：
10.1093/jrr/rrs053
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发表时间：
2013-01
影响因子：
2
通讯作者：
Nakano T
中科院分区：
文献类型：
--
作者：
Subedi KS;Takahashi T;Yamano T;Saitoh J;Nishimura K;Suzuki Y;Ohno T;Nakano T
本研究的目的是比较T1加权磁共振成像的单剂量对比剂管理协议和双剂量对比剂管理协议之间的转移性脑肿瘤的总肿瘤体积（GTV）的大小和清晰度，以确定立体定向放射治疗（SRT）中清晰描绘GTV的最佳对比增强剂量。在13例患者中，通过使用单剂量和双剂量对比增强薄层（1 mm）磁共振成像（MRI）对GTV测量值进行个体内比较，共评估了28个小转移性脑肿瘤。所有患者均确认了原发性肿瘤的组织学类型，并接受了转移性脑肿瘤的低分割SRT。单次增强和双次增强的平均肿瘤直径分别为12.0 ± 1.1mm和13.2 ± 1.1mm（P < 0.001）。通过比较平均肿瘤直径获得的平均增量比（MIR）为11.2 ± 0.02%。GTV-1（单次增强）和GTV-2（双次增强）的平均体积分别为1.38 ± 0.41ml和1.59 ± 0.45ml（P < 0.01）。通过比较平均肿瘤体积，MIR为32.3 ± 0.4%。1 ml体积的GTV-1的MIR< 1ml volume and GTV-1 with >分别为41.8 ± 0.05%和12.4 ± 0.03%（P < 0.001）。我们的结论是，双剂量对比增强薄层MRI是一个更有用的技术比单剂量对比增强薄层MRI，特别是在高精度的SRT治疗计划的小转移性脑肿瘤的GTV的清晰描绘。
The purpose of this study was to compare the size and clearness of gross tumor volumes (GTVs) of metastatic brain tumors on T1-weighted magnetic resonance images between a single dose contrast administration protocol and a double dose contrast administration protocol to determine the optimum dose of contrast-enhancement for clear delineation of GTV in stereotactic radiotherapy (SRT). A total of 28 small metastatic brain tumors were evaluated in 13 patients by intra-individual comparison of GTV measurements using single dose and double dose contrast-enhanced thin-slice (1-mm) magnetic resonance imaging (MRI). All patients had confirmed histological types of primary tumors and had undergone hypo-fractionated SRT for metastatic brain tumors. The mean tumor diameter with single dose and double dose contrast-enhancement was 12.0 ± 1.1 mm and 13.2 ± 1.1 mm respectively (P < 0.001). The mean incremental ratio (MIR) obtained by comparing mean tumor diameters was 11.2 ± 0.02 %. The mean volume of GTV-1 (single dose contrast-enhancement) and GTV-2 (double dose contrast-enhancement) was 1.38 ± 0.41 ml and 1.59 ± 0.45 ml respectively (P < 0.01). The MIR by comparing mean tumor volumes was 32.3 ± 0.4 %. The MIR of GTV-1 with < 1ml volume and GTV-1 with > 1ml volume was 41.8 ± 0.05 % and 12.4 ± 0.03 % respectively (P < 0.001). We conclude that double dose contrast-enhanced thin-slice MRI is a more useful technique than single dose contrast-enhanced thin-slice MRI, especially for clear delineation of GTVs of small metastatic brain tumors in treatment planning of highly precise SRT.
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影响因子：
6.7
作者：
Brekenfeld, C;Foert, E;Gehl, HB
通讯作者：
Gehl, HB
DOI：
10.1016/j.ijrobp.2006.02.062
发表时间：
2006-01-01
影响因子：
7
作者：
Takahashi, Takeo;Nishimura, Keiichiro;Honda, Norinari
通讯作者：
Honda, Norinari
影响因子：
1.7
作者：
Engh, Johnathan A.;Flickinger, John C.;Lunsford, L. Dade
通讯作者：
Lunsford, L. Dade
DOI：
10.1016/s0360-3016(99)00507-6
发表时间：
2000-05-01
影响因子：
7
作者：
Shaw, E;Scott, C;Farnan, N
通讯作者：
Farnan, N
影响因子：
3.9
作者：
Schellinger, PD;Meinck, HM;Thron, A
通讯作者：
Thron, A