Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells.
Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells.
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同种异体抗原识别之前是细胞毒性 T 细胞和靶细胞的非特异性粘附。
DOI：
10.1126/science.3485822
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
deVries,JE
中科院分区：
文献类型：
--
作者：
Spits,H;vanSchooten,W;Keizer,H;vanSeventer,G;vandeRijn,M;Terhorst,C;deVries,JE
只有当抗原暴露在细胞表面时，t细胞受体才会与抗原结合。这可以在细胞溶解T淋巴细胞（CTL）与靶细胞的相互作用中进行最好的研究，因为识别和结合事件可以从裂解期分离出来。对HLA-A2和HLA-B7特异性CTL克隆的研究表明，在没有特异性抗原识别的情况下，CTL和靶细胞可以形成缀合物。此外，t细胞受体和靶抗原不能相互作用，除非有偶联物形成。这表明CTL与靶细胞之间的非特异性偶联形成先于t细胞受体对特异性抗原的识别。
T-cell receptors bind antigens only when the antigens are exposed on the cell surface. This can be studied best in the interaction of cytolytic T lymphocytes (CTL) with target cells because the recognition and binding event can be separated from the lytic phase. Studies with CTL clones specific for HLA-A2 and HLA-B7 demonstrated that conjugates of CTL's and target cells can be formed in the absence of specific-antigen recognition. Furthermore, T-cell receptor and target antigen cannot interact unless there is conjugate formation. This indicates that nonspecific conjugate formation between CTL's and target cells precedes the recognition of specific antigen by the T-cell receptor.