The roles of Sarcophaga defense molecules in immunity and metamorphosis
The roles of Sarcophaga defense molecules in immunity and metamorphosis
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DOI：
10.1016/s0145-305x(99)00014-2
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发表时间：
1999-06-01
影响因子：
2.9
通讯作者：
Kobayashi, A
中科院分区：
文献类型：
--
作者：
Natori, S;Shiraishi, H;Kobayashi, A
本文总结了近年来（1996-1998）我们在游隼自卫分子方面的研究进展。纯化了一种新的抗菌物质，其独特的结构和功能揭示了游隼防御系统的一个新方面。我们在血细胞中发现了一种新的凝集素和半胱氨酸蛋白酶，这将有助于理解血细胞的免疫反应。防御基因诱导调节的研究取得了两项重大进展：（i）与Sarcophaga凝集素基因的κB样启动子序列结合的新转录因子的cDNA克隆，（ii）诱导防御基因所必需的胞质因子的甲基化 从免疫学的角度来看，变态是一个有趣的事件：（i）从变态肠道中发现了一种具有抗菌活性的新型蛋白酶，（ii）纯化了蛹血细胞特异性表面抗原，并对其结构和幼虫组织识别和消除的可能功能进行了表征。 (C) 1999 Elsevier Science Ltd. 保留所有权利。
This article summarizes recent progress (1996-1998) in our studies on self-defense molecules in Sarcophaga peregrina.A new antibacterial substance was purified and its unique structure and function revealed a novel aspect of the Sarcophaga defense system. We found a novel lectin and cysteine protease in hemocytes which will assist in the understanding of immune response of hemocytes.There have been two major advances in research on the regulation of defense gene induction: (i) cDNA cloning of a new transcriptional factor binding to the kappa B-like promoter sequence of the Sarcophaga lectin gene, (ii) methylation of cytosolic factors essential for induction of immune genes in the fatbody.Metamorphosis is an interesting event from an immunological point of view: (i) a novel protease with antibacterial activity was discovered from metamorphosing gut, and (ii) a pupal hemocyte-specific surface antigen was purified and characterized in terms of its structure and possible function for larval tissue recognition and elimination. (C) 1999 Elsevier Science Ltd. All rights reserved.