CODON USAGE IN PSEUDOMONAS-AERUGINOSA

CODON USAGE IN PSEUDOMONAS-AERUGINOSA
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DOI:
10.1093/nar/16.19.9323
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发表时间:
1988-10-11
影响因子:
14.9
通讯作者:
IGLEWSKI, BH
IGLEWSKI, BH
中科院分区:
生物学2区
文献类型:
--
作者:
WEST, SEH;IGLEWSKI, BH

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我们已经生成了铜绿假单胞菌的密码子使用表。铜绿假单胞菌中的密码子使用是非常有偏见的。与E.在大肠杆菌和酵母中,铜绿假单胞菌优先使用具有最强预测密码子-反密码子相互作用的同义密码子组内的那些密码子。我们无法将特定的密码子使用模式与预测的mRNA表达水平相关联。第三个碱基的选择反映了铜绿假单胞菌基因组的高鸟嘌呤加胞嘧啶含量(67.2%),并且胞嘧啶是第三个密码子位置的优选核苷酸。
We have generated a codonusage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressively. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.