Neuropeptide Y potentiates norepinephrine-stimulated inositol phosphate production in the rat tail artery.
Neuropeptide Y potentiates norepinephrine-stimulated inositol phosphate production in the rat tail artery.
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神经肽 Y 增强大鼠尾动脉中去甲肾上腺素刺激的磷酸肌醇的产生。
DOI：
10.1016/0024-3205(94)90101-5
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发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Buxton,IL
中科院分区：
文献类型：
--
作者：
Duckles,SP;Buxton,IL
We have recently demonstrated the ability of neuropeptide Y to augment norepinephrine-sti, ulated contractions of rat tail artery. In [3 H] myo-inositol labeled segments of rat tail artery, addition of a concentration of neuropeptide Y (10− 8 M) known to potentiate contractile responses produced no effect on the basal accumulation of [3 H] inositol phosphates. Addition of norepinephrine (10− 7 M), however, resulted in the rapid accumulation of [3 H] inositol 1, 4, 5-trisphosphate to 325±29% of basal levels within 5 min. This effect of norepinephrine on [3 H] inositol 1, 4, 5-trisphosphate accumulation was mirrored by significant increases (274±25% of control) in total [3 H] inositol phosphates. When neuropeptide Y and norepinephrine were added together, the norepinephrine-stimulated increase in [3 H] inositol 1, 4, 5-trisphosphate was significantly augmented (467±35% of control) as was the increase measured in total [3 H] inositol phosphates (366±21% of control). We suggest that the ability of neuropeptide Y to augment norepinephrine-induced contraction of the rat tail artery is due, at least in part, to the ability of neuropeptide Y to increase norepinephrine-stimulated phospholipase C activity in vascular smooth muscle and may represent the mechanism of action of this co-neurotransmitter in vivo.
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DOI：
--
发表时间：
1989
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
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DOI：
--
发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
1985
期刊：
Acta Physiologica Scandinavica
影响因子：
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作者：
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通讯作者：
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影响因子：
5.2
作者：
C. Wahlestedt;L. Grundemar;R. Håkanson;M. Heilig;G. Shen;Z. Żukowska;D. Reis
通讯作者：
D. Reis