Cold-induced metabolism
Cold-induced metabolism
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DOI：
10.1097/01.mco.0000078992.96795.5f
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发表时间：
2003-07-01
影响因子：
3.1
通讯作者：
Dannen, HAM
中科院分区：
文献类型：
--
作者：
Lichtenbelt, WDV;Dannen, HAM
观察到的寒冷反应的巨大个体差异的含义是，对寒冷的低代谢反应可以部分解释肥胖风险的增加。环境因素和遗传因素对非颤抖性产热的影响都需要更好的对照研究。随着对这些因素的深入了解，可以确定是否可能有一种药理学方案，它将模拟慢性感冒或升高的儿茶酚胺水平的影响，而没有伴随的副作用。
The implications of the observed large individual variation in cold response is that a low metabolic response to cold can partly explain increased risk to develop obesity. Both the effect of environmental factors and genetic factors on nonshivering thermogenesis require more well controlled studies. With extended knowledge on these factors it can be ascertained if a pharmacological regimen is possible which would mimic the effects of chronic cold or elevated catecholamine levels, without attendant side effects.