High frequency of cryptic deleterious mutations in Caenorhabditis elegans
High frequency of cryptic deleterious mutations in Caenorhabditis elegans
复制标题
DOI：
10.1126/science.285.5434.1748
复制
发表时间：
1999-09-10
期刊：
影响因子：
56.9
通讯作者：
Keightley, PD
中科院分区：
文献类型：
--
作者：
Davies, EK;Peters, AD;Keightley, PD
具有非常小的表型效应的有害突变可能对几种进化现象很重要，但它们的贡献程度尚不清楚。采用一种可以估计DNA中有害点突变数量的系统来测量秀丽隐杆线虫系中诱导突变的适应度效应。在适应度分析中，每个品系中固定的有害突变只有大约4%可以检测到。剩下的96%，虽然是隐式的，但对突变负载和潜在的性别进化都很重要。
Deleterious mutations with very small phenotypic effects could be important for several evolutionary phenomena, but the extent of their contribution has been unknown. Fitness effects of induced mutations in Lines of Caenorhabditis elegans were measured using a system for which the number of deleterious point mutations in the DNA can be estimated. In fitness assays, only about 4 percent of the deleterious mutations fixed in each Line were detectable. The remaining 96 percent, though cryptic, are significant for mutation Load and, potentially, for the evolution of sex.