Simultaneous PET-MRI:: a new approach for functional and morphological imaging
Simultaneous PET-MRI:: a new approach for functional and morphological imaging
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DOI：
10.1038/nm1700
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发表时间：
2008-04-01
期刊：
影响因子：
82.9
通讯作者：
Pichler, Bernd J.
中科院分区：
文献类型：
--
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
分子水平的非侵入性成像是生物医学研究中的一个新兴领域。本文介绍了一种新的技术协同两个领先的成像方法：正电子发射断层扫描（PET）和磁共振成像（MRI）。尽管PET的价值在于其在体内对生物标志物的高灵敏度追踪，但其缺乏分辨形态学。磁共振成像的灵敏度较低，但产生高的软组织对比度，并提供光谱信息和功能磁共振成像（fMRI）。我们已经开发出一种三维动物PET扫描仪，内置于7- T MRI中。我们的评估表明，这两种方式保持其功能，即使在等时操作。利用这种组合成像系统，我们同时获得了活体小鼠的功能和形态PET-MRI数据。PET- MRI为临床前研究提供了研究生物学和病理学的有力工具，具有很大的临床应用潜力。将功能磁共振成像和光谱学与PET结合起来，为分子成像的新视角铺平了道路。
Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography ( PET) and magnetic resonance imaging ( MRI). Although the value of PET lies in its high- sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft- tissue contrast and provides spectroscopic information and functional MRI ( fMRI). We have developed a three- dimensional animal PET scanner that is built into a 7- T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET- MRI data from living mice. PET- MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.