Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study
Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study
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DOI：
10.1097/hjh.0b013e32835c5c23
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发表时间：
2013-03-01
影响因子：
4.9
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Ninomiya, Toshiharu;Kojima, Iwao;Kiyohara, Yutaka
目的：我们研究了日本普通人群臂踝脉搏波速度与心血管疾病发展之间的关系。方法：共有2916名年龄在40岁以上、无心血管疾病史的日本社区居民接受了平均7.1年的随访，采用考克斯比例风险模型估计臂踝脉搏波传导速度与心血管危险度的关系。为了比较调整已知的心血管危险因素与无臂踝脉搏波传导速度的模型之间的心血管事件的风险评估的准确性，在接受者工作特征曲线和净重新分类改善的面积calculated.Results：在随访期间，126例患者经历了心血管事件。年龄和性别校正后的心血管疾病发病率随臂踝脉搏波速度水平的升高而线性增加（趋势P
Objective: We examined the relationship between brachial-ankle pulse wave velocity and the development of cardiovascular disease in a general Japanese population.Methods: A total of 2916 community-dwelling Japanese individuals without history of cardiovascular disease aged at least 40 years were followed up for an average of 7.1 years, and the relationship between brachial-ankle pulse wave velocity and the cardiovascular risk was estimated using the Cox proportional hazards model. To compare the accuracy of the risk assessment for cardiovascular events between the models adjusted for known cardiovascular risk factors with and without brachial-ankle pulse wave velocity, the area under the receiver-operating characteristic curve and net reclassification improvement were computed.Results: During the follow-up period, 126 patients experienced cardiovascular events. Age and sex-adjusted incidence rates of cardiovascular disease increased linearly with elevating brachial-ankle pulse wave velocity levels (P for trend