PROZONE PHENOMENON IN SECONDARY SYPHILIS - HAS ITS TIME ARRIVED
PROZONE PHENOMENON IN SECONDARY SYPHILIS - HAS ITS TIME ARRIVED
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DOI：
10.1001/archinte.153.21.2496
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发表时间：
1993-11-08
影响因子：
--
通讯作者：
MARTIN, PD
中科院分区：
文献类型：
--
作者：
JURADO, RL;CAMPBELL, J;MARTIN, PD
我们介绍了三名梅毒患者，其中存在前带现象--非常高的抗体滴度，导致在未稀释的标本中出现假阴性测试。我们的三名患者中有一人人类免疫缺陷病毒(HIV)呈阳性，另一人有HIV感染的风险，并有一些与HIV感染相适应的临床结果(该患者是在HIV血清学测试可用之前发现的)。我们认为，HIV感染，通过其B细胞调节失调，可能导致较高的非梅毒螺旋体血清学滴度，增加了前地带现象在HIV阳性的梅毒患者中比在HIV阴性的梅毒患者中更普遍的可能性。
We present three patients with syphilis in which the prozone phenomenon was present-a very high antibody titer, leading to a false-negative test in undiluted specimens. One of our three patients was positive for human immunodeficiency virus (HIV), another was at risk for HIV infection, and had some clinical findings compatible with HIV infection (this patient was seen before HIV serologic tests were available). We propose that HIV infection, by its B-cell dysregulation, may lead to higher nontreponemal serologic titers, raising the possibility that the prozone phenomenon may be more prevalent in HIV-positive individuals with syphilis than in luetic patients who are negative for HIV.