White matter alterations in the dorsal attention network contribute to a high risk of unsafe driving in healthy older people
White matter alterations in the dorsal attention network contribute to a high risk of unsafe driving in healthy older people
复制标题
背部注意力网络中的白质改变导致健康老年人不安全驾驶的高风险
DOI：
10.1002/pcn5.45
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yamagata Bun
中科院分区：
文献类型：
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作者：
Yamamoto Yasuharu;Hirano Jinichi;Ueda Ryo;Yoshitake Hiroshi;Yamagishi Mika;Kimura Mariko;Kamiya Kei;Shino Motoki;Mimura Masaru;Yamagata Bun
健康的老年司机可能有很高的致命交通事故风险。我们最近的研究表明，在健康的老年人中，背侧注意网络(DAN)内大脑区域灰质的体积变化与不安全驾驶的风险密切相关。然而，健康老年人脑白质(WM)结构连通性与驾驶能力之间的关系尚不清楚。方法我们使用扩散张量成像技术，在健康老年人中检测DAN的微结构改变与不安全驾驶风险之间的关系。我们招募了32名年龄在65岁以上的健康老年人，并使用道路驾驶测试来筛选不安全的司机。结果分析表明，与安全驾驶员相比，不安全驾驶员在9个WM簇中具有显著更高的轴向扩散系数。这些结果主要见于参与DAN的背侧上纵束。此外，相关分析表明，在不安全的司机中，上纵束的轴向弥散系数值较高与较低的Trail Making Test A分数有关。这一结果表明，在功能上，DAN中WM微结构的改变与注意力问题有关，这可能导致健康老年人不安全驾驶的风险。结论我们的发现可能阐明健康老年人不安全驾驶风险增加的神经生物学机制，可能有助于开发新的干预措施来预防致命事故。
AimHealthy older drivers may be at high risk of fatal traffic accidents. Our recent study showed that volumetric alterations in gray matter in the brain regions within the dorsal attention network (DAN) were strongly related to the risk of unsafe driving in healthy older people. However, the relationship between white matter (WM) structural connectivity and driving ability in healthy older people is still unclear.MethodsWe used diffusion tensor imaging to examine the association between microstructural alterations in the DAN and the risk of unsafe driving among healthy older people. We enrolled 32 healthy older individuals aged over 65 years and screened unsafe drivers using an on‐road driving test. We then determined the pattern of WM aberrations in unsafe drivers using tract‐based spatial statistics.ResultsThe analysis demonstrated that unsafe drivers had significantly higher axial diffusivity values in nine WM clusters compared with safe drivers. These results were primarily observed bilaterally in the dorsal superior longitudinal fasciculus, which is involved in the DAN. Furthermore, correlation analyses showed that higher axial diffusivity values in the superior longitudinal fasciculus were associated with lower Trail Making Test A scores within unsafe drivers. This result suggests that functionally, WM microstructural alterations in the DAN are associated with attention problems, which may contribute to the risk of unsafe driving among healthy older people.ConclusionOur findings may elucidate the neurobiological mechanisms underlying the increased risk of unsafe driving in healthy older people, potentially facilitating the development of new interventions to prevent fatal accidents.