Modification of Food Cariogenicity in Rats by Mineral-rich Concentrates from Milk
Modification of Food Cariogenicity in Rats by Mineral-rich Concentrates from Milk
复制标题
牛奶中富含矿物质的浓缩物对大鼠食物致龋性的改变
DOI：
10.1177/00220345870660010901
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发表时间：
1987
影响因子：
7.6
通讯作者：
J. Hefferren
中科院分区：
文献类型：
--
作者：
D. S. Harper;J. C. Osborn;R. Clayton;J. Hefferren
根据在各种动物、牙菌斑酸度和体外系统中的测量，乳制品，包括牛奶、奶酪和酪蛋白，可以降低致龋底物的致龋潜力。尽管负责保护的机制尚未完全确定，但含有 Ca 和 P 的物质可能通过减少脱矿质和/或促进牙釉质再矿化来发挥保护潜力。酪蛋白可以通过在牙釉质表面形成保护层来减少脱矿质。通过大鼠模型，本研究评估了三种含有不同水平乳清蛋白、钙和磷酸盐的无酪蛋白牛奶矿物质浓缩物改变含有 20% 蔗糖的粉状饮食的致龋性的能力。对这些数据的分析表明，根据基于计算机的红外活动监测器的监测，各组之间的体重增加、食物消耗总量或喂食频率没有显着差异。所有三种矿物质浓缩物均显着减少颊面龋齿，三种矿物质中的两种可减少龈沟龋齿 10% 至 30%。分析进一步表明，无酪蛋白的牛奶矿物质成分可以改变大鼠模型中含蔗糖食物的致龋性。
Dairy products, including milk, cheese, and casein, can reduce the caries-causing potential of cariogenic substrates as measured in various animal, plaque acidity, and in vitro systems. Although the mechanisms responsible for protection are not completely identified, substances containing Ca and P may contribute to the protective potential by reducing demineralization and/or promoting remineralization of enamel. Casein may reduce demineralization by forming a protective coat on the enamel surface. By means of a rat model, this study evaluated the ability of three casein-free milk mineral concentrates with various levels of whey protein, calcium, and phosphate to modify the cariogenicity of a powdered diet containing 20% sucrose. Analysis of these data indicates that there were no significant differences among groups for weight gain, total food consumption, or feeding frequency, as monitored by a computer-based infrared activity monitor. All three mineral concentrates significantly reduced buccal caries, and two of the three reduced sulcal caries by from 10 to 30%. The analysis further shows that casein-free milk mineral fractions can modify the cariogenicity of sucrose-containing foods in a rat model.