IN-SITU HYBRIDIZATION MAPPING OF A 500-KDA CALCIUM-SENSING PROTEIN GENE (LRP2) TO HUMAN-CHROMOSOME REGION 2Q31-]Q32.1 AND PORCINE CHROMOSOME REGION 15Q22-]Q24
IN-SITU HYBRIDIZATION MAPPING OF A 500-KDA CALCIUM-SENSING PROTEIN GENE (LRP2) TO HUMAN-CHROMOSOME REGION 2Q31-]Q32.1 AND PORCINE CHROMOSOME REGION 15Q22-]Q24
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DOI：
10.1159/000134088
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
RASK, L
中科院分区：
文献类型：
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作者：
CHOWDHARY, BP;LUNDGREN, S;RASK, L
最近，一个500 kDa的蛋白质，与大鼠Gp330糖蛋白的同源性，被发现表达在人甲状旁腺，胎盘细胞滋养层，和肾近端小管细胞的表面上。该蛋白质被认为是甲状旁腺和胎盘细胞滋养层细胞上细胞外钙的传感器。我们在此报告了相应基因（命名为低密度脂蛋白受体相关蛋白-2，符号为LRP 2）在人染色体区域2q31 → q32.1和猪染色体区域15q22 → q24的原位杂交定位。结果进行了讨论，比较映射的上下文中。
Recently, a 500-kDa protein, with homology to the rat Gp330 glycoprotein, was found to be expressed on the surface of human parathyroid, placental cytotrophoblast, and renal proximal tubule cells. The protein has been implicated to function as a sensor of extracellular calcium on parathyroid and placental cytotrophoblast cells. We report here in situ hybridization mapping of the corresponding gene, designated as low-density lipoprotein receptor related protein-2 and symbolized as LRP2, to human chromosome region 2q31→q32.1 and porcine chromosome region 15q22→q24. The results are discussed in a comparative mapping context.