Height and Site-specific Cancer Risk: A Cohort Study of a Korean Adult Population
Height and Site-specific Cancer Risk: A Cohort Study of a Korean Adult Population
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DOI：
10.1093/aje/kwp088
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发表时间：
2009-07-01
影响因子：
5
通讯作者：
Ebrahim, Shah
中科院分区：
文献类型：
--
作者：
Sung, Joohon;Song, Yun-Mi;Ebrahim, Shah
为了评估东亚中等收入人群的身高与癌症风险之间的关系，作者在1994年至2003年期间对788，789名韩国人（449，214名男性和339，575名女性）进行了癌症发病率随访，年龄在40-64岁之间。考克斯比例风险回归分析用于评估相关性。在调整年龄、体重指数、行为和社会经济因素后，身高每增加5厘米，男性和女性的所有部位癌症风险分别增加5%和7%。当评估特定部位癌症的相关性时，在男性和女性中观察到结肠癌和甲状腺癌的正相关性。在性别特异性癌症中，前列腺癌与男性的身高呈正相关。在女性中，身高与乳腺癌和卵巢癌之间存在正相关，即使在对生殖因素进行额外调整后也没有改变。虽然需要更多的澄清，一些特定部位的癌症，同样的正相关性的高度与癌症在中等收入的韩国人群中发现在高收入的西方人群支持早期生活环境的影响，在成年期癌症的发展。
To evaluate the association between height and risk of cancer in an East Asian, middle-income population, the authors followed up a cohort of 788,789 Koreans (449,214 men and 339,575 women) aged 40-64 years for cancer incidence between 1994 and 2003. Cox proportional hazards regression analysis was used to evaluate the association. Each 5-cm increment in height was associated with 5% and 7% higher risk of all-sites cancer in men and women, respectively, after adjustment for age, body mass index, and behavioral and socioeconomic factors. When the associations were evaluated for site-specific cancers, a positive association was observed for cancer of the colon and thyroid in both men and women. Among gender-specific cancers, prostate cancer was positively associated with height in men. In women, there was a positive association between height and cancers of the breast and ovary, which did not change even after additional adjustment for reproductive factors. Although more clarification is needed for some site-specific cancers, the same positive association of height with cancer in a middle-income Korean population as found in high-income Western populations supports the influence of early life environment on cancer development in adulthood.