Synthesis and biological evaluation of novel inhibitors against 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea
Synthesis and biological evaluation of novel inhibitors against 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea
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新型稻瘟病菌1,3,8-三羟基萘还原酶抑制剂的合成及生物学评价
DOI：
10.1016/j.bmc.2016.01.053
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发表时间：
2016-03-15
影响因子：
3.5
通讯作者：
Wan, Jian
中科院分区：
文献类型：
--
作者：
Chen, Haifeng;Han, Xinya;Wan, Jian
1，3，8-三羟基萘还原酶（3 HNR）是真菌黑色素生物合成的关键酶。根据3 HNR活性中心的结构信息，合理设计合成了一系列β-硝基苯乙烯类化合物。对这些化合物的酶活性测定表明，大部分化合物具有较高的抑制活性，
1,3,8-Trihydroxynaphthalene reductase (3HNR) is an essential enzymes that is involved in fungal melanin biosynthesis. Based on the structural informations of active site of 3HNR, a series of beta-nitrostyrene compounds were rationally designed and synthesized. The enzymatic activities of these compounds showed that most of them exhibited high inhibitory activities (