The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.
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DOI:
10.1038/nchem.1002
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发表时间:
2011-04
期刊:
影响因子:
21.8
通讯作者:
--
中科院分区:
化学1区
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埃米利亚尼亚是一种环境重要的海洋微藻,它的生活方式是大起大落,大量的藻类出现和消退。Gallaecisis属于变形杆菌属(α-Protebacteria)的玫瑰杆菌分支,其种群数量的消长与胡克斯莱肠杆菌的种群数量的消长有关。玫瑰杆菌被认为通过生物合成和分泌抗生素和生长刺激剂(生长素)来促进藻类的生长。在这里,我们展示了Gallaecisis将其分泌的小分子代谢转换为有效和选择性的杀藻剂的生产,以响应p-香豆酸,一种藻类木质素分解产物,是老化藻类的症状。这种转换将半乳链霉菌转化为其藻类宿主的机会性病原体。
Emiliania huxleyi, an environmentally important marine microalga, has a bloom- and-bust lifestyle in which massive algal blooms appear and fade. Phaeobacter gallaeciensis belongs to the roseobacter clade of α-Proteobacteria, whose populations wax and wane with that of E. huxleyi. Roseobacter are thought to promote algal growth by biosynthesizing and secreting antibiotics and growth stimulants (auxins). Here we show that P. gallaeciensis switches its secreted small molecule metabolism to the production of potent and selective algaecides, the roseobacticides, in response to p-coumaric acid, an algal lignin breakdown product that is symptomatic of aging algae. This switch converts P. gallaeciensis into an opportunistic pathogen of its algal host.
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发表时间: 1993-12-01
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