Extrusion printed polymer structures: A facile and versatile approach to tailored drug delivery platforms
Extrusion printed polymer structures: A facile and versatile approach to tailored drug delivery platforms
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DOI：
10.1016/j.ijpharm.2011.11.007
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发表时间：
2012-01-17
影响因子：
5.8
通讯作者：
Wallace, Gordon G.
中科院分区：
文献类型：
--
作者：
Rattanakit, Parawee;Moulton, Simon E.;Wallace, Gordon G.
一种新的挤出印刷系统用于产生药物递送结构，其中地塞米松-21-磷酸二钠盐（Dex 21 P）被封装在可生物降解的聚合物（PLGA）和水溶性聚（乙烯醇）（PVA）构型内。证明了通过打印的三维结构内的药物的空间分布来控制药物释放曲线的能力。制造的配置，其特征在于通过光学显微镜和SEM来评估表面形态。结果清楚地表明地塞米松成功地包封在层压的PLGA：PVA结构内。从结构得到的药物释放曲线显示两阶段释放曲线，具有明显不同的释放速率和观察到的最小初始突释。在4个月的时间内监测地塞米松释放。这种方法清楚地表明，挤出印刷技术提供了一种简便和通用的方法来制造新的药物递送平台。(c)2011 Elsevier B. V.保留所有权利。
A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through the spatial distribution of drug within the printed 3-dimensional structures is demonstrated. The fabricated configurations were characterised by optical microscopy and SEM to evaluate surface morphology. The results clearly demonstrate the successful encapsulation of dexamethasone within a laminated PLGA: PVA structure. The resulting drug release profiles from the structures show a two stage release profile with distinctly different release rates and minimal initial burst release observed. Dexamethasone release was monitored over a 4-month period. This approach clearly demonstrates that the extrusion printing technique provides a facile and versatile approach to fabrication of novel drug delivery platforms. (c) 2011 Elsevier B.V. All rights reserved.