A classification for the interferon-tau.
A classification for the interferon-tau.
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发表时间：
2000
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影响因子：
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通讯作者：
A. P. Alexenko;A. Ealy;J. Bixby;R. Roberts
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文献类型：
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作者：
A. P. Alexenko;A. Ealy;J. Bixby;R. Roberts
基于系统发育分析和常见的氨基酸替换，对GenBank中的干扰素-tau（interferon-tau，IFN-tau）序列进行了合理的组织，为建立统一的命名方案奠定了基础。自从这些基因首次被发现以来的13年里，大量的cDNA和基因序列被报道，有理由怀疑所有主要的绵羊和牛类型的代表现在都被描述了。这些数据与绵羊和牛中存在许多基因和等位基因变体相一致，类似于在人类中观察到的IFN-α。未来的变化应该很容易适应这里概述的计划。一个灵活的命名系统，用于HuIFN的基础上，需要提供一个共同的基础，在不同的实验室进行的研究之间的比较，并分配相对的生物效力，这些分子。
An attempt has been made to provide a rational organization for the many interferon-tau (IFN-tau) sequences entered in GenBank based on phylogenetic analysis and common amino acid substitutions, which might form the basis for a universal nomenclature scheme. Over the 13 years since these genes were first discovered, large numbers of cDNA and gene sequences have been reported, and there is reason to suspect that representatives of all the major ovine and bovine forms have now been described. The data are consistent with the presence of many genes and also allelic variants in sheep and cattle analogous to what has been observed for the IFN-alpha in the human. Future variants should be easily accommodated into the scheme outlined here. A flexible system of nomenclature, based on that used for HuIFN, is needed to provide a common base for comparison between research done in different laboratories and to assign relative biologic potencies to these molecules.