Neural plate progenitors give rise to both anterior and posterior pituitary cells
Neural plate progenitors give rise to both anterior and posterior pituitary cells
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DOI：
10.1016/j.devcel.2023.08.018
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发表时间：
2023-12-04
影响因子：
11.8
通讯作者：
Levkowitz，Gil
中科院分区：
文献类型：
--
作者：
Chen，Qiyu;Leshkowitz，Dena;Levkowitz，Gil
脑垂体是主要的神经内分泌腺，它调节身体的稳态。它由含有激素产生细胞的垂体前叶/腺垂体和垂体后叶/神经垂体组成，后者将激素从大脑传递到外周。一般认为腺垂体起源于口腔外胚层（Rathke氏囊），而神经外胚层则形成神经垂体。斑马鱼脑垂体的单细胞转录组学显示cyp 26 b1阳性的神经垂体星形胶质细胞和prop 1阳性的腺垂体祖细胞表达共同的标志物，这意味着谱系相关。遗传追踪表明，与流行的教条相反，斑马鱼（her4.3+）和小鼠（Sox 1+）的神经板前体有助于神经垂体和腺垂体细胞的子集。垂体后叶细胞衍生的视黄酸降解酶Cyp 26 b1微调prop 1+祖细胞分化为分泌细胞这些结果挑战的概念，腺垂体细胞完全来自非神经外胚层，并表明，神经和腺垂体细胞之间的串扰影响垂体细胞的分化。
The pituitary is the master neuroendocrine gland, which regulates body homeostasis. It consists of the anterior pituitary/adenohypophysis harboring hormones producing cells and the posterior pituitary/neurohypophysis, which relays the passage of hormones from the brain to the periphery. It is accepted that the adenohypophysis originates from the oral ectoderm (Rathke's pouch), whereas the neural ectoderm contributes to the neurohypophysis. Single-cell transcriptomics of the zebrafish pituitary showed thatcyp26b1-positive astroglial pituicytes of the neurohypophysis andprop1-positive adenohypophyseal progenitors expressed common markers implying lineage relatedness. Genetic tracing identifies that, in contrast to the prevailing dogma, neural plate precursors of zebrafish (her4.3+) and mouse (Sox1+) contribute to both neurohypophyseal and a subset of adenohypophyseal cells. Pituicyte-derived retinoic-acid-degrading enzyme Cyp26b1 fine-tunes differentiation ofprop1+progenitors into hormone-producing cells. These results challenge the notion that adenohypophyseal cells are exclusively derived from non-neural ectoderm and demonstrate that crosstalk between neuro- and adeno-hypophyseal cells affects differentiation of pituitary cells.