Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget.
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget.
复制标题
INPP4B 的缺失会通过 BRCA1、ATM 和 ATR 的缺失导致 DNA 修复缺陷,并且可以通过 PARP 抑制剂治疗来靶向。
作者:
Ip LR;Poulogiannis G;Viciano FC;Sasaki J;Kofuji S;Spanswick VJ;Hochhauser D;Hartley JA;Sasaki T;Gewinner CA.