OPTIC ATROPHY IN CYSTIC FIBROSIS OF THE PANCREAS.
OPTIC ATROPHY IN CYSTIC FIBROSIS OF THE PANCREAS.
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胰腺囊性纤维化中的视神经萎缩。
DOI：
10.1016/0002-9394(65)93002-3
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
E. Collins
中科院分区：
文献类型：
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作者：
V. Wong;E. Collins
布鲁斯和他的同事首先描述了患有胰腺囊性纤维化的儿童的眼部变化。1观察到24例中重度肺部疾病患者的眼科异常。主要的眼底改变是视网膜静脉增生和乳头水肿。三个孩子有双侧中央暗斑，其中两个在他们的一般情况得到证实后消失。另外三名患者的眼睛进行了组织学检查，支持检眼镜的发现。据推测，所有患者都接受过广泛的抗生素治疗。当时还没有研究这种治疗在产生眼部变化中可能起的作用。然而，在最近的报道中，Denning2和Huang3注意到视神经受累与氯胺酚长期化疗之间的可能联系。
Ocular changes in children with cystic fibrosis of the pancreas were first described by Bruce and co-workers. 1 Ophthalmologic abnormalities were observed in 24 patients with moderate to severe pulmonary disease. The predominant fundus changes were en gorgement of the retinal veins and papil ledema. Three children had bilateral central scotomas which disappeared in two of them when their general condition im proved. The eyes of three other patients were examined histologically and supported the ophthalmoscopic findings. All patients presumably had been treated extensively with antibiotics. The role which such treat ment may have played in producing the eye changes was not investigated at that time. In recent reports, however, Denning2 and Huang3 drew attention to the possible con nection between the optic-nerve involvement and prolonged chemotherapy with chloram phenicol.