Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala
Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala
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DOI：
10.1073/pnas.1407018111
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发表时间：
2014-06-17
影响因子：
11.1
通讯作者：
Welsh, Michael J.
中科院分区：
文献类型：
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作者：
Du, Jianyang;Reznikov, Leah R.;Welsh, Michael J.
刺激突触前末端可以增加突触中的质子浓度。质子的潜在受体是酸敏感离子通道（asic）， Na+-和Ca2+渗透通道，可被细胞外酸中毒激活。这些观察结果表明，质子可能是一种神经递质。我们发现突触前刺激会瞬间降低杏仁核的细胞外pH值。质子激活外侧杏仁核锥体神经元的asic，产生兴奋性突触后电流。此外，质子和asic对侧杏仁核神经元的突触可塑性都是必需的。结果确定质子是一种神经递质，并建立asic作为突触后受体。他们还指出，质子和asic是对杏仁核依赖性学习和记忆至关重要的神经递质/受体对。
Stimulating presynaptic terminals can increase the proton concentration in synapses. Potential receptors for protons are acid-sensing ion channels (ASICs), Na+- and Ca2+-permeable channels that are activated by extracellular acidosis. Those observations suggest that protons might be a neurotransmitter. We found that presynaptic stimulation transiently reduced extracellular pH in the amygdala. The protons activated ASICs in lateral amygdala pyramidal neurons, generating excitatory postsynaptic currents. Moreover, both protons and ASICs were required for synaptic plasticity in lateral amygdala neurons. The results identify protons as a neurotransmitter, and they establish ASICs as the postsynaptic receptor. They also indicate that protons and ASICs are a neurotransmitter/receptor pair critical for amygdala-dependent learning and memory.