Neural stem cell niches: roles for the hyaluronan-based extracellular matrix.
Neural stem cell niches: roles for the hyaluronan-based extracellular matrix.
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DOI：
10.2741/218
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Sherman LS
中科院分区：
文献类型：
--
作者：
Preston M;Sherman LS
神经干/祖细胞能够分化成神经元和神经胶质细胞，这些细胞分布在哺乳动物中枢神经系统（CNS）中，在特定的神经干细胞龛中持续存在，这些神经干细胞龛调节干细胞的增殖、存活和分化。越来越多的证据表明，神经干细胞龛内的细胞外基质是神经干细胞维持所必需的。在这里，我们回顾研究结果支持糖胺聚糖透明质酸（HA）及其跨膜受体在神经干/祖细胞增殖，分化和成熟的关键作用。我们还概述了研究结果，支持HA的作用不断变化，因为细胞在大脑和脊髓中变得致力于不同的谱系。
Neural stem/progenitor cells capable of differentiating into the neurons and glial cells that populate the mammalian central nervous system (CNS) persist in specific neural stem cell niches that regulate stem cell proliferation, survival and differentiation. There is growing evidence that the extracellular matrix within neural stem cell niches is required for neural stem cell maintenance. Here, we review findings supporting a pivotal role for the glycosaminoglycan hyaluronan (HA) and its transmembrane receptors in neural stem/progenitor cell proliferation, differentiation and maturation. We also outline findings supporting changing roles for HA as cells become committed to distinct lineages in the brain and spinal cord.