Segmentation of microcystic macular edema in Cirrus OCT scans with an exploratory longitudinal study.
Segmentation of microcystic macular edema in Cirrus OCT scans with an exploratory longitudinal study.
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通过探索性纵向研究对 Cirrus OCT 扫描中的微囊性黄斑水肿进行分割。
DOI：
10.1117/12.2082164
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Calabresi,PeterA
中科院分区：
文献类型：
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作者：
Swingle,EmilyK;Lang,Andrew;Carass,Aaron;Al-Louzi,Omar;Saidha,Shiv;Prince,JerryL;Calabresi,PeterA
微囊性黄斑水肿（MME）是用于描述人视网膜内核层（INL）中的假囊状空间的术语。多发性硬化症（MS）以及各种其他疾病都有这种现象。导致MME形成的过程及其随时间的变化尚未得到充分解释。MME在如此不同的患者组中发生的低比率使得这种病理的鉴定和一致的定量对于发展患者特异性疾病是重要的。在视网膜的光学相干断层扫描（OCT）中观察到MME，其表现为光反射率的变化，其模式提示称为假性囊肿的液体积聚。在较高信噪比（SNR）的图像中可以很容易地识别出假性囊肿，然而在较低SNR的扫描中，假性囊肿可能无法与噪声区分开来。在这项工作中，我们扩展了我们早期的MME识别方法对Spectralis OCT扫描处理较低质量的卷云OCT扫描。我们的方法使用一个随机森林分类器，训练手动分割的10个科目，自动检测MME。该算法具有一个真正的阳性率MME识别为0.95和一个骰子得分为0.79。我们包括一个初步的纵向研究，在四到五年，探讨纵向变化的MME。复发缓解型MS和视神经肌萎缩症的患者似乎有动态的假性囊肿体积，而MME体积出现稳定的一个患者与原发性进行性MS。
Microcystic macular edema (MME) is a term used to describe pseudocystic spaces in the inner nuclear layer (INL) of the human retina. It has been noted in multiple sclerosis (MS) as well as a variety of other diseases. The processes that lead to MME formation and their change over time have yet to be explained sufficiently. The low rate at which MME occurs within such diverse patient groups makes the identification and consistent quantification of this pathology important for developing patient-specific prognoses. MME is observed in optical coherence tomography (OCT) scans of the retina as changes in light reflectivity in a pattern suggestive of fluid accumulations called pseudocysts. Pseudocysts can be readily identified in higher signal-to-noise ratio (SNR) images, however pseudocysts can be indistinguishable from noise in lower SNR scans. In this work, we expand upon our earlier MME identification methods on Spectralis OCT scans to handle lower quality Cirrus OCT scans. Our approach uses a random forest classifier, trained on manual segmentation of ten subjects, to automatically detect MME. The algorithm has a true positive rate for MME identification of 0.95 and a Dice score of 0.79. We include a preliminary longitudinal study of three patients over four to five years to explore the longitudinal changes of MME. The patients with relapsing-remitting MS and neuromyelitis optica appear to have dynamic pseudocyst volumes, while the MME volume appears stable in the one patient with primary progressive MS.