Trends in Indications and Techniques of Corneal Transplantation in Iran from 2006 to 2013; an 8-year Review.
Trends in Indications and Techniques of Corneal Transplantation in Iran from 2006 to 2013; an 8-year Review.
复制标题
DOI：
10.4103/2008-322x.183930
复制
发表时间：
2016-04
影响因子：
2
通讯作者：
Safi S
中科院分区：
文献类型：
--
作者：
Rezaei Kanavi M;Javadi MA;Motevasseli T;Chamani T;Rezaei Kanavi M;Kheiri B;Safi S
报告伊朗角膜移植适应证和技术的变化趋势。我们回顾了2006年至2013年间在伊朗不同眼科中心接受角膜移植的47129名患者的眼库记录。角膜移植最常见的适应症是圆锥角膜（KCN, n = 21,350眼，45.3%），其次是大疱性角膜病变（BK, n = 8,566眼，18.2%）、角膜混浊和瘢痕（COS, n = 7,158眼，15.2%）、移植失败（n = 3,252眼，6.9%）、角膜营养不良（n = 2,553眼，5.4%）和感染性角膜炎（n = 2,238眼，4.7%）。在研究期间，BK （P = 0.001）和移植物失败（P = 0.025）的频率显著增加，COS的相对频率显著降低（P = 0.012）。KCN （P = 0.172）、感染性角膜炎（P = 0.107）和角膜营养不良（P = 0.836）的患病率保持不变。最常见的角膜移植技术是穿透性角膜移植术（PKP, n = 33476眼，71.0%），其次是深前板层角膜移植术（DALK, n = 8363眼，17.7%）、Descemet剥离自动内皮角膜移植术（DSAEK, n = 3516眼，7.5%）、构造（n = 1752眼，3.7%）和角膜缘异体移植（KLAL, n = 19眼，0.1%）。关于手术技术的改变，在8年的时间里，DSAEK显著增加（P < 0.001）， PKP显著降低（P = 0.005）。DALK （P = 0.354）、构造接枝（P = 0.999）和KLAL （P = 0.151）发生率无显著变化。KCN是最常见的适应症，PKP是角膜移植中最常用的技术。在过去的8年中，手术技术发生了重大变化；DSAEK呈上升趋势，PKP呈下降趋势。
To report changing trends in indications and techniques of corneal transplantation in Iran. We reviewed eye bank records of 47,129 patients who had undergone corneal transplantation between 2006 and 2013 at different eye centers throughout Iran. The most common indication for corneal transplantation was keratoconus (KCN, n = 21,350 eyes, 45.3%), followed by bullous keratopathy (BK, n = 8,566 eyes, 18.2%), corneal opacity and scar (COS, n = 7,158 eyes, 15.2%), graft failure (n = 3,252 eyes, 6.9%), corneal dystrophies (n = 2,553 eyes, 5.4%), and infectious keratitis (n = 2,238 eyes, 4.7%). Over the study period, there was a significant increase in the frequency of BK (P = 0.001) and graft failure (P = 0.025), and a significant decrease in the relative frequency of COS (P = 0.012). The prevalence of KCN (P = 0.172), infectious keratitis (P = 0.107), and corneal dystrophies (P = 0.836) remained unchanged. The most common technique of corneal transplantation was penetrating keratoplasty (PKP, n = 33,476 eyes, 71.0%), followed by deep anterior lamellar keratoplasty (DALK, n = 8,363 eyes, 17.7%), Descemet's stripping automated endothelial keratoplasty (DSAEK, n = 3,516 eyes, 7.5%), tectonic (n = 1752, 3.7%), and keratolimbal allograft (KLAL, n = 19 eyes, 0.1%). Regarding the shift in surgical techniques, a significant increase was observed in DSAEK (P < 0.001), whereas PKP was significantly decreased (P = 0.005) over the 8-year period. No significant change was seen in the rates of DALK (P = 0.354), tectonic graft (P > 0.999) and KLAL (P = 0.151). KCN was the most common indication and PKP was the most prevalent technique used for corneal transplantation. Significant changes in surgical techniques were observed over the past 8 years; DSAEK demonstrated an increasing trend while PKP showed a decrease.