Renal blood flow autoregulation in developing swine.
Renal blood flow autoregulation in developing swine.
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发育中猪的肾血流自动调节。
DOI：
10.1152/ajpheart.1983.245.1.h1
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Frasier,ID
中科院分区：
文献类型：
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作者：
Buckley,NM;Brazeau,P;Frasier,ID
在62只1日龄~ 2月龄的猪上，用戊巴比妥钠麻醉，测定了肾循环的压力-流量关系（P/F）。记录主动脉和下腔静脉压力以及肾动脉和股动脉血流。监测血气成分、pH值和体温。首先测定P/F，同时通过肾上主动脉阻断在每个压力下降低灌注压2 min。然后对其中38只动物的左肾动脉插管，通过Masterflex泵从颈动脉抽取血液，原位灌注肾脏。随后通过在每个流量下改变泵流量2分钟同时记录灌注压来确定P/F。分析记录的瞬态和稳态效应。肾血管阻力（RVR）的重新调整在改变压力或流量后5秒内明显。RVR稳定在一个新的水平在2分钟内。稳态数据的图形描绘了一个自动调节范围内的P/F为年轻的2周龄的动物。我们的结论是，在这种哺乳动物的肾血流自动调节是可以忽略不计，在出生后的第一个月逐步发展。
Pressure-flow relationships (P/F) in the renal circulation were determined in 62 swine, aged 1 day-2 mo, anesthetized with pentobarbital sodium. Aortic and inferior vena caval pressures and renal and femoral arterial flows were recorded. Blood gas composition and pH and body temperature were monitored. The P/F was first determined while perfusion pressure was decreased for 2 min at each pressure by suprarenal aortic occlusion. The left renal artery in 38 of these animals was then cannulated for in situ perfusion of the kidney with blood withdrawn from a carotid artery by a Masterflex pump. The P/F was subsequently determined by changing pump flow for 2 min at each flow while recording perfusion pressure. Records were analyzed for transient and steady-state effects. Readjustments in renal vascular resistance (RVR) were apparent within 5 s after changing pressure or flow. The RVR stabilized at a new level within 2 min. Graphs of steady-state data delineated an autoregulatory range in the P/F for animals as young as 2 wk of age. We conclude that renal blood flow autoregulation in this mammal is negligible at birth and develops progressively during the first postnatal month.