Prostatic inflammation and obstructive voiding in the adult Noble rat: Impact of the testosterone to estradiol ratio in serum
Prostatic inflammation and obstructive voiding in the adult Noble rat: Impact of the testosterone to estradiol ratio in serum
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DOI：
10.1002/pros.20791
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发表时间：
2008-09-01
期刊：
影响因子：
2.8
通讯作者：
Streng, Tomi
中科院分区：
文献类型：
--
作者：
Bernoulli, Jenni;Yatkin, Emrah;Streng, Tomi
背景血清中睾酮/雌二醇（T/E-2）比值的年龄相关性下降与前列腺炎症和下尿路症状的患病率增加相关，提示梗阻性排尿。在成年Noble大鼠中测试T与E-2比率对非细菌性前列腺炎症和梗阻性排尿的发展和逆转的影响。成年雄性Noble大鼠（n = 16）用雌二醇（83 μ g/天）和两种不同剂量（280和830 μ g/天）的睾酮处理，以引起低雄激素和高雄激素状态，同时升高雌激素。激素治疗13周后，在麻醉下进行尿动力学测量和横纹括约肌电活动记录。测量血清中睾酮、雌二醇和催乳素的浓度，并对前列腺背外侧的炎症变化进行分类和计数。组织学和尿动力学分析表明，T/E-2比值降低（10 vs> 300对照组）的低雄激素动物出现前列腺炎症和非梗阻性排尿。雄激素过多状态伴T/E-2比值降低至50时，可降低前列腺炎症的侵袭性和前列腺腺泡的数量，并导致尿道梗阻伴横纹括约肌功能障碍。前列腺炎症和排尿功能对T/E-2比值变化的不同反应表明，非细菌性前列腺炎症不是梗阻性排尿发展的充分条件。目前的研究发现，没有支持的想法，年龄和/或肥胖相关的低雄激素状态与T-到-E-2的比例下降会导致尿道梗阻。
BACKGROUND. The age-related decline of the testosterone to estradiol (T-to-E-2) ratio in serum is associated with the increased prevalence of prostatic inflammation and lower urinary tract symptoms suggesting obstructive voiding. The impact of the T-to-E-2 ratio on the development and reversal of non-bacterial prostatic inflammation and obstructive voiding was tested in adult Noble rats.METHODS. Adult male Noble rats (n = 16) were treated with estradiol (83 mu g/day) and two different doses (280 and 830 mu g/day) of testosterone to cause hypoandrogenic and hyperandrogenic states with elevated estrogen. After the 13-week hormonal treatment, urodynamical measurements and electrical activity recording of the rhabdosphincter muscle were performed under anesthesia. Testosterone, estradiol, and prolactin concentrations in serum were measured and inflammatory changes in the dorsolateral prostate were classified and counted.RESULTS. Histopathological and urodynamical analyses indicated that the hypoandrogenic animals with a decreased T-to-E-2 ratio (10 versus > 300 in control) developed prostatic inflammation and non-obstructive voiding. The hyperandrogenic state with decreased T-to-E-2 ratio of 50 decreased the aggressiveness of the inflammation and the number of inflamed acini in the prostate and caused urethral obstruction associated with rhabdosphincter dysfunction.CONCLUSIONS. Different responses of the prostatic inflammation and voiding function to the change in T-to-E-2 ratio imply that non-bacterial prostatic inflammation is not a sufficient condition for the development of obstructive voiding. The present study finds no support for the idea that age- and/or obesity-related hypoandrogenic state with a decreased ratio of T-to-E-2 would cause urethral obstruction.