Dissociation between postprandial lipemia and high density lipoprotein cholesterol concentrations in endurance-trained men.
Dissociation between postprandial lipemia and high density lipoprotein cholesterol concentrations in endurance-trained men.
复制标题
接受耐力训练的男性餐后血脂与高密度脂蛋白胆固醇浓度之间的关联。
DOI：
10.1161/01.atv.11.4.838
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Grundy,SM
中科院分区：
文献类型：
--
作者：
Cohen,JC;Stray-Gundersen,J;Grundy,SM
先前的研究表明，循环高密度脂蛋白（HDL）浓度与乳糜微粒清除率呈反比关系。由于长期运动已被证明可以增加乳糜微粒的清除，我们测量了耐力训练男性对高脂（140克）和低脂（50克）膳食的高密度脂蛋白胆固醇浓度和血浆甘油三酯和棕榈酸视黄酯的反应。这些男性的血浆高密度脂蛋白胆固醇浓度在36到105毫克/分升之间。高密度脂蛋白胆固醇浓度的个体内变异主要发生在高密度脂蛋白2。与先前报道的久坐不动的男性相比，高脂餐和低脂餐引起的餐后血脂水平一致较低，且与高密度脂蛋白胆固醇浓度无关。反映乳糜微粒残余代谢的餐后棕榈酸视黄醇浓度也与高密度脂蛋白胆固醇浓度无相关性。这些数据表明，在耐力训练的男性中，餐后血脂的程度并不是高密度脂蛋白胆固醇浓度的主要决定因素。因此，在这些男性中测量到的高密度脂蛋白胆固醇浓度的大范围必须归因于其他因素。
Previous studies have indicated an inverse relation between circulating high density lipoprotein (HDL) concentrations and the rate of chylomicron clearance. Because chronic exercise has been shown to augment chylomicron clearance, we measured HDL cholesterol concentrations and plasma triglyceride and retinyl palmitate responses to high- (140 g) and low- (50 g) fat meals in endurance-trained men. Plasma HDL cholesterol concentrations in these men ranged from 36 to 105 mg/dl. Intraindividual variation in the cholesterol concentration of the HDLs occurred primarily in HDL2. The magnitude of postprandial lipemia induced by both the high- and the low-fat meals was uniformly low compared with values reported previously for sedentary men and was not correlated with HDL cholesterol concentrations. Postprandial retinyl palmitate concentrations, which reflect chylomicron remnant metabolism, also showed no correlation with HDL cholesterol concentrations. These data indicate that the degree of postprandial lipemia is not the primary determinant of HDL cholesterol concentrations in endurance-trained men. Accordingly, the wide range of HDL cholesterol concentrations measured in these men must be attributable to other factors.