Biocompatibility testing of branched and linear polyglycidol
Biocompatibility testing of branched and linear polyglycidol
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DOI：
10.1021/bm0504882
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发表时间：
2006-03-01
影响因子：
6.2
通讯作者：
Brooks, DE
中科院分区：
文献类型：
--
作者：
Kainthan, RK;Janzen, J;Brooks, DE
聚乙二醇是一种灵活的亲水性聚醚，基于其与被充分研究的聚乙二醇的相似性，是潜在的生物相容性聚合物。通过合适的合成方法，聚乙二醇可以制备成支链聚合物或线性聚合物。本文报道了这些聚合物在体外和体内进行的生物相容性测试。体外研究包括血液相容性测试对凝血的影响（PT和APTT）、补体激活、红细胞聚集和全血粘度测量。并进行了体外细胞毒性实验。结果与一些已经在人类使用的常见生物相容性聚合物进行了比较。这些研究结果表明，聚糖醇具有高度的生物相容性。研究发现，即使注射高剂量的超支化多糖醇，小鼠也能很好地耐受。
Polyglycidols are flexible hydrophilic polyethers that are potentially biocompatible polymers based on their similarities to the well-studied poly(ethyleneglycol). Polyglycidols can be prepared as branched or linear polymers by suitable synthetic methods. Biocompatibility testing of these polymers conducted in vitro as well as in vivo are reported here. The in vitro studies included hemocompatibility testing for effects on coagulation (PT and APTT), complement activation, red blood cell aggregation, and whole blood viscosity measurements. In vitro cytotoxicity experiments were also conducted. The results were compared with some of the common biocompatible polymers already in human use. Results from these studies show that polyglycidols are highly biocompatible. Hyperbranched polyglycidols were found to be well tolerated by mice even when injected in high doses.