Spectroscopic optical coherence tomography for classification of colorectal cancer in a mouse model.
Spectroscopic optical coherence tomography for classification of colorectal cancer in a mouse model.
复制标题
光谱光学相干断层扫描用于小鼠模型中结直肠癌的分类。
DOI：
10.1002/jbio.202100387
复制
发表时间：
2022
影响因子：
2.8
通讯作者：
Wax,Adam
中科院分区：
文献类型：
--
作者：
Kendall,WesleyY;Bordas,Julianna;Mirminachi,Seyedbabak;Joseph,Abel;Roper,Jatin;Wax,Adam
非侵入性诊断结肠息肉的恶性潜能可以改善结直肠癌的预防，而不需要耗时和昂贵的活组织检查。这项研究使用光谱光学相干断层扫描(OCT)对基因工程小鼠模型的早期腺瘤(APC)和晚期腺癌(AKP)组织进行分类，在这些模型中，肿瘤是在远端结肠诱导的。通过分析组织的成像数据，评估了组织的散射功率和散射衰减系数的光学性质。分类是使用二维线性判别分析生成的，获得了高水平的判别。总的分类准确率为91.5%，区分良性肿瘤的敏感性和特异性分别为100%和96.7%，区分腺癌和非恶性组织的敏感性和特异性分别为77.8%和99.4%。因此，本研究证明了光谱OCT在结肠腺瘤和结直肠癌快速检测中的临床应用潜力。
Noninvasive diagnosis of the malignant potential of colon polyps can improve prevention of colorectal cancer without the need for time‐consuming and expensive biopsies. This study examines the use of spectroscopic optical coherence tomography (OCT) to classify tissue from genetically engineered mouse models of early‐stage adenoma (APC) and advanced adenocarcinoma (AKP) in which tumors are induced in the distal colon. The optical tissue properties of scattering power and scattering attenuation coefficient are evaluated by analyzing the imaging data collected from tissues. Classifications are generated using 2D linear discriminant analysis with high levels of discrimination obtained. The overall classification accuracy obtained was 91.5%, with 100% sensitivity and 96.7% specificity in separating tumors from benign tissue, and 77.8% sensitivity and 99.4% specificity in separating adenocarcinoma from nonmalignant tissue. Thus, this study demonstrates the clinical potential of using spectroscopic OCT for rapid detection of colon adenoma and colorectal cancer.