Cyclic deposition of calcium salts during growth of cholesterol gallstones.
Cyclic deposition of calcium salts during growth of cholesterol gallstones.
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发表时间：
1985
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通讯作者：
P. Malet;N. Weston;B. Trotman;R. Soloway
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作者：
P. Malet;N. Weston;B. Trotman;R. Soloway
有些胆固醇结石含有深色素中心或周边同心色素带。我们检查了三个胆固醇结石的横截面表面，其中包括中央和周边色素区与电子探针显微分析（EDS）和能量色散X射线显微分析（EDXA），以确定色素区的元素组成。横跨结石横截面的线性双折射显示，所有三种结石的大部分色素沉着区域具有高Ca和P信号;非色素沉着的中间区域具有明显较低或不可检测的Ca和P信号。在三个结石中的两个中，高O信号与高Ca和P信号相一致，这表明在这些色素区域中存在胆红素钙和磷酸钙。每个结石的中央和外周色素区的EDXA证实了高Ca信号的存在。我们的研究结果表明，在某些胆固醇结石中，存在着胆红素钙和其他钙盐的循环沉积。
Some cholesterol gallstones contain darkly pigmented centers or peripheral concentric pigmented bands. We examined the cross-sectional surface of three cholesterol gallstones which contained both central and peripheral pigmented areas with electron-probe microanalysis (EPM) and energy dispersive x-ray microanalysis (EDXA) to determine the elemental composition of the pigmented regions. Linear EPM across the cross-sectional surface of the stones demonstrated that most of the pigmented regions of all three stones had high Ca and P signals; the non-pigmented intervening areas had markedly lower or no detectable Ca and P signals. In two of the three stones, high O signals coincided with the high Ca and P signals suggesting that both calcium bilirubinate and calcium phosphate were present in these pigmented areas. EDXA of the central and peripheral pigmented areas of each stone confirmed the presence of a high Ca signal. Our results demonstrate that in some cholesterol gallstones there is cyclic deposition of calcium bilirubinate and other calcium salts.