Effect of interferons and poly(I):poly(C) on the pathogenesis of the diabetogenic variant of encephalomyocarditis virus in different mouse strains.
Effect of interferons and poly(I):poly(C) on the pathogenesis of the diabetogenic variant of encephalomyocarditis virus in different mouse strains.
复制标题
干扰素和聚（I）：聚（C）对不同小鼠品系脑心肌炎病毒糖尿病变体发病机制的影响。
DOI：
10.1089/jir.1988.8.745
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
D. C. Thomas
中科院分区：
文献类型：
--
作者：
D. Giron;H. Agostini;D. C. Thomas
Interferon (IFN) can either prevent or exacerbate the pathogenic effects of the diabetogenic variant of encephalomyocarditis (EMC-D) virus. The effect seen is dependent upon the mouse strain and the time of IFN administration. For example, IFN-alpha beta protects SWR/J but not ICR Swiss male mice against the diabetogenic effects of the virus. Administration of either IFN-alpha beta or the IFN-inducer poly(I):poly(C) 4 days post infection, results in an exacerbation of the infection in ICR Swiss and C57BL/6 male mice. Studies have been initiated to investigate the role of the IFN system in the pathogenesis of this virus infection. In this study IFNs or poly(I):poly(C) were administered to several mouse strains at 24 h before or 4 days after infection with EMC-D virus. The results of such treatment ranged from complete protection of the animals from the diabetogenic effects of the virus to exacerbation of the infection as reflected by the virus content in selected organs. The effect was dependent upon the mouse strain, the type of IFN, and the time of its administration in relation to virus infection.
干扰素诱导剂抑制病毒诱导的小鼠糖尿病。
DOI：
10.1089/jir.1982.2.59
发表时间：
1982
期刊：
Journal of interferon research
影响因子：
--
作者：
Gadzik,JP;Naji,A;Barker,CF;Blank,KJ
通讯作者：
Blank,KJ