Decoding of Context-Dependent Olfactory Behavior in Drosophila
Decoding of Context-Dependent Olfactory Behavior in Drosophila
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DOI：
10.1016/j.neuron.2016.05.022
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发表时间：
2016-07-06
期刊：
影响因子：
16.2
通讯作者：
Kazama, Hokto
中科院分区：
文献类型：
--
作者：
Badel, Laurent;Ohta, Kazumi;Kazama, Hokto
气味信息编码在初级嗅觉中心的肾小球群体的活动中。然而，这些信息如何在大脑中解码仍然是难以捉摸的。在这里，我们解决这个问题在果蝇结合神经元成像和先天行为反应的跟踪。我们发现，该行为是准确预测的模型总结归一化肾小球反应，其中每个肾小球有助于特定的，少量的气味偏好。该模型进一步得到肾小球输入的有针对性的操纵的支持，这使行为偏向。此外，我们观察到相对气味偏好会发生变化，甚至可以根据上下文进行切换，这是我们的归一化模型正确预测的效果。我们的研究结果表明，嗅觉信息解码从汇集活动的肾小球剧目，并证明嗅觉系统的能力，以适应其环境的统计。
Odor information is encoded in the activity of a population of glomeruli in the primary olfactory center. However, how this information is decoded in the brain remains elusive. Here, we address this question in Drosophila by combining neuronal imaging and tracking of innate behavioral responses. We find that the behavior is accurately predicted by a model summing normalized glomerular responses, in which each glomerulus contributes a specific, small amount to odor preference. This model is further supported by targeted manipulations of glomerular input, which biased the behavior. Additionally, we observe that relative odor preference changes and can even switch depending on the context, an effect correctly predicted by our normalization model. Our results indicate that olfactory information is decoded from the pooled activity of a glomerular repertoire and demonstrate the ability of the olfactory system to adapt to the statistics of its environment.