A direct test of the diathesis-stress model for depression.
A direct test of the diathesis-stress model for depression.
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DOI：
10.1038/mp.2017.130
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发表时间：
2018-07
影响因子：
11
通讯作者：
Martin NG
中科院分区：
文献类型：
--
作者：
Colodro-Conde L;Couvy-Duchesne B;Zhu G;Coventry WL;Byrne EM;Gordon S;Wright MJ;Montgomery GW;Madden PAF;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Ripke S;Eaves LJ;Heath AC;Wray NR;Medland SE;Martin NG
抑郁的素质-压力理论认为，压力对抑郁风险的影响取决于素质或脆弱性，这意味着在负债量表上存在乘性交互作用。我们使用根据精神病学基因组学联盟的最新分析结果计算的严重抑郁障碍(MDD)的多基因风险分数，作为对来自3083个家庭的5 221名个体样本中抑郁易感性的直接测量。与此同时，我们还测量了应激性生活事件和社会支持，并对大多数人进行了抑郁症状评分，以及DSM-IV MDD诊断。为了估计由遗传易损性、应激源及其相互作用所解释的抑郁症的方差，我们对整个样本以及按性别分层的控制相关性的线性混合模型进行了拟合。我们发现，多基因风险得分与个人生活事件(解释方差的0.12%，p值=0.0076)之间存在显著的交互作用，对抑郁风险有积极的贡献。此外，我们的结果表明，女性和男性在抑郁症的病因上可能存在差异。总而言之，我们的发现指出，具有综合脆弱性和大量报告的个人生活事件的个人的额外风险超出了这些因素对抑郁易感性的相加贡献，支持了这种疾病的乘性素质-压力模型。
The diathesis-stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability scale. We used polygenic risk scores for major depressive disorder (MDD) calculated from the results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of the vulnerability for depression in a sample of 5 221 individuals from 3 083 families. In the same we also had measures of stressful life events and social support and a depression symptom score, as well as DSM-IV MDD diagnoses for most individuals. In order to estimate the variance in depression explained by the genetic vulnerability, the stressors and their interactions, we fitted linear mixed models controlling for relatedness for the whole sample as well as stratified by sex. We show a significant interaction of the polygenic risk scores with personal life events (0.12% of variance explained, p-value=0.0076) contributing positively to the risk of depression. Additionally, our results suggest possible differences in the aetiology of depression between women and men. In conclusion, our findings point to an extra risk for individuals with combined vulnerability and high number of reported personal life events beyond what would be expected from the additive contributions of these factors to the liability for depression, supporting the multiplicative diathesis-stress model for this disease.
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影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
DOI：
10.1111/j.2044-8317.1977.tb00722.x
发表时间：
1977-01-01
影响因子：
2.6
作者：
EAVES, LJ;LAST, K;JINKS, JL
通讯作者：
JINKS, JL
DOI：
10.1002/ajmg.b.31044
发表时间：
2010-04-01
影响因子：
2.8
作者：
Coventry, William L.;James, Michael R.;Wray, Naomi R.
通讯作者：
Wray, Naomi R.
影响因子：
--
作者：
Bierut, LJ;Heath, AC;Martin, NG
通讯作者：
Martin, NG
影响因子：
3.7
作者：
Haberstick BC;Boardman JD;Wagner B;Smolen A;Hewitt JK;Killeya-Jones LA;Tabor J;Halpern CT;Brummett BH;Williams RB;Siegler IC;Hopfer CJ;Mullan Harris K
通讯作者：
Mullan Harris K